3,3'-Biindolenyliden | 38292-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,3'-Biindolenyliden
• 英文别名: [3,3']biindolylidene；3,3'-Biindolyl；3-indol-3-ylideneindole
• CAS: 38292-48-7
• 化学式: C₁₆H₁₀N₂
• 分子量: 230.269
• InChiKey: JFTINOPCCDRQDG-UHFFFAOYSA-N

物化性质

• 沸点：
  429.1±45.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Conjugate of Benzofuranone and Indole or Azaindole, and Preparation and Uses Thereof
  申请人：LUODA BIOSCIENCES, INC.

  公开号：US20160185771A1

  公开（公告）日：2016-06-30

  The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.

  本发明涉及一种酮基吲哚蓝或异靛蓝衍生物，一种酮基氮杂吲哚蓝或异靛蓝衍生物，以及它们的光学异构体、消旋体、顺反异构体和药学上可接受的盐，可用于制备治疗或预防葡萄糖代谢紊乱、炎症或自身免疫疾病、神经退行性疾病、精神疾病、组织增生疾病或肿瘤等疾病的药物。
• Indolylpyrrole derivatives and cell death inhibitors
  申请人：——

  公开号：US20030087949A1

  公开（公告）日：2003-05-08

  The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exacerbation thereof: 1 and, a cell death inhibitor, a drug or a preservative for cells, organs or tissues or cells, each comprising the derivative as an active ingredient.

  本发明提供了一种化合物，其化学式表示为(I)，可用于抑制细胞死亡。该药物预期可作为预防或治疗各种细胞死亡参与病程和恶化的疾病的药物，同时还提供了一种细胞死亡抑制剂、细胞、器官或组织的药物或保护剂，每种药物均包含该衍生物作为活性成分。
• Treatment of protein folding disorders
  申请人：Carter D. Michael

  公开号：US20070015813A1

  公开（公告）日：2007-01-18

  In certain embodiments, the invention is directed to a method for treating a protein folding disorder comprising administering to a subject a compound of the formulas disclosed. In preferred embodiments, the compounds are bis-indole compounds.

  在某些实施例中，本发明涉及一种治疗蛋白质折叠紊乱的方法，包括向受试者给予公开的配方的化合物。在优选实施例中，这些化合物是双吲哚化合物。
• INDOLYLPYRROLE DERIVATIVES AND CELL DEATH INHIBITORS
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1275646A1

  公开（公告）日：2003-01-15

  The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exacerbation thereof: and, a cell death inhibitor, a drug or a preservative for cells, organs or tissues or cells, each comprising the derivative as an active ingredient.

  本发明提供了一种由下式(I)代表的化合物，该化合物可用于抑制细胞死亡，该药物可望作为各种疾病的预防或治疗药物，在这些疾病中，细胞死亡参与了疾病的进展和恶化： 以及细胞死亡抑制剂、细胞、器官或组织或细胞的药物或防腐剂，每一种都包含该衍生物作为活性成分。
• CONJUGATE OF BENZOFURANONE AND INDOLE OR AZAINDOLE, AND PREPARATION AND USES THEREOF
  申请人：Luoda Biosciences, Inc.

  公开号：EP3006442A1

  公开（公告）日：2016-04-13

  The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.

  本发明涉及一种氧代靛蓝或异靛蓝衍生物、一种氧氮靛蓝或异靛蓝衍生物及其光学异构体、外消旋体、顺/反式异构体和药学上可接受的盐，可用于制备治疗或预防疾病的药物，如糖代谢紊乱、炎症或自身免疫性疾病、神经退行性疾病、精神疾病、组织增生疾病或肿瘤。