bupivacaine diclofenac salt | 1043449-43-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: bupivacaine diclofenac salt
• 英文别名: 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• CAS: 1043449-43-9
• 化学式: C₁₄H₁₁Cl₂NO₂*C₁₈H₂₈N₂O
• 分子量: 584.586
• InChiKey: IHGCQMZTHBLETE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.26
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.7
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• A PHARMACEUTICAL COMPOSITION COMPRISING A DELIVERY SYSTEM, AN AMIDE-TYPE LOCAL ANESTHETIC, AND MELOXICAM
  申请人：Heron Therapeutics, Inc.

  公开号：EP3509601A1

  公开（公告）日：2019-07-17
• [EN] A PHARMACEUTICAL COMPOSITION COMPRISING A DELIVERY SYSTEM, AN AMIDE-TYPE LOCAL ANESTHETIC, AND MELOXICAM<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT UN SYSTÈME D'ADMINISTRATION, UN ANESTHÉSIQUE LOCAL DE TYPE AMIDE ET UN MÉLOXICAM
  申请人：HERON THERAPEUTICS INC

  公开号：WO2018048460A1

  公开（公告）日：2018-03-15

  Compositions comprised of a delivery vehicle or delivery system and an active agent dispersed within the delivery vehicle or system, wherein the delivery vehicle or system contains a polyorthoester polymer and a polar aprotic solvent. Also disclosed are low viscosity delivery systems for administration of active agents. The low viscosity delivery systems have a polyorthoester polymer, a polar aprotic solvent and a solvent containing a triglyceride viscosity reducing agent. Compositions described include an amide- or anilide-type local anesthetic of the "caine" classification, and a non¬ steroidal anti-inflammatory drug (NSAID), along with related methods, e.g., for treatment of post¬ operative pain or for prophylactic treatment of pain. The compositions are suitable for delivery via, e.g., direct application and instillation, intradermal injection, subcutaneous injection, and nerve block (perineural).