(4.5.8-trimethyl-phenanthryl-(1))-acetic acid | 112297-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (4.5.8-trimethyl-phenanthryl-(1))-acetic acid
• 英文别名: (4.5.8-Trimethyl-phenanthryl-(1))-essigsaeure；1-Carboxymethyl-4.5.8-trimethyl-phenanthren；4,5,8-Trimethyl-1-phenanthreneacetic acid；2-(4,5,8-trimethylphenanthren-1-yl)acetic acid
• CAS: 112297-21-9；116819-38-6；116819-39-7
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.351
• InChiKey: SKKZFBKFPSZDJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 碘 作用下， 以7%的产率得到(4.5.8-trimethyl-phenanthryl-(1))-acetic acid
  参考文献：
  名称：

  Mannschreck, Albrecht; Gmahl, Erich; Burgemeister, Thomas, Angewandte Chemie, 1988, vol. 100, # 2, p. 299 - 301

  摘要：

  DOI：

文献信息

• The Synthesis and Optical Resolution of 4,5,8-Trimethyl-1-phenanthrylacetic Acid¹
  作者：Melvin S. Newman、Allen S. Hussey

  DOI：10.1021/ja01204a026

  日期：1947.12
• Aging and time-sharing aspects of executive control
  作者：Timothy A. Salthouse、James D. Miles

  DOI：10.3758/bf03194958

  日期：2002.6

  A particularly important aspect of executive functioning involves the ability to coordinate two simultaneous activities. The role of this aspect of executive functioning in adult-age differences in cognitive performance was examined in a study involving 150 adults between 20 and 91 years of age who performed the same visual-motor tracking task with three different primary tasks. The participants also performed several additional cognitive tasks that allowed examination of the relation of time-sharing efficiency to other types of cognitive functioning. The results were consistent with the existence of a distinct time-sharing ability because the time-sharing costs in the three dual-task combinations were significantly correlated with one another but only weakly correlated with other cognitive variables. Increased age was associated with reductions in time-sharing ability, and greater efficiency in performing two tasks at once was associated with better performance on tasks assessing spatial, reasoning, and memory abilities. Although this pattern is what one would expect if executive processes contribute to age differences in cognitive functioning, the effects were smaller than those associated with a perceptual speed construct.
• MANNSCHRECK, ALBRECHT;GMAHL, ERICH;BURGEMEISTER, THOMAS;KASTNER, FRITZ;SI+, ANGEW. CHEM., 100,(1988) N, C. 299-301
  作者：MANNSCHRECK, ALBRECHT、GMAHL, ERICH、BURGEMEISTER, THOMAS、KASTNER, FRITZ、SI+

  DOI：——

  日期：——
• Mannschreck, Albrecht; Gmahl, Erich; Burgemeister, Thomas, Angewandte Chemie, 1988, vol. 100, # 2, p. 299 - 301
  作者：Mannschreck, Albrecht、Gmahl, Erich、Burgemeister, Thomas、Kastner, Fritz、Sinnwell, Volker

  DOI：——

  日期：——