d(C6) | 72672-33-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: d(C6)
• 英文别名: [(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-[[[(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl] [(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate
• CAS: 72672-33-4
• 化学式: C₅₄H₇₃N₁₈O₃₄P₅
• 分子量: 1673.14
• InChiKey: UQMSFLREPFFYMY-WJZHHMPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -13.7
• 重原子数：
  111
• 可旋转键数：
  32
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  727
• 氢给体数：
  13
• 氢受体数：
  34

反应信息

• 作为反应物：
  描述：

  苯甲酰氯 、 d(C6) 在 吡啶 作用下， 反应 24.0h， 生成
  参考文献：
  名称：

  具有磷酸三酯键的六聚体 d(TpTpTpTpTpT) 的平行右手双链体

  摘要：

  本文提出Cr(CO)5-和O2之间产生Cr(CO)302-和Cr(CO)的离子-分子反应是通过竞争反应机制发生的。这两种机制涉及 (i) 简单的配体交换以产生 Cr(CO),O, 阴离子和 (ii) 将 O2 添加到 Cr(CO)，然后将 0- 分子内亲核添加到 CO 配体以形成 Cr (CO)、O-和CO加CO 2 。观察到 Cr(CO) < 与 O 2 反应速率的惊人大的温度依赖性。反应速率的强烈温度依赖性归因于高能 [Cr(CO),-] * 物种的形成。高能 Cr(CO), 阴离子可以通过 Cr(CO)6 的热分解形成高自旋态的 Cr(CO)5，随后通过电子附着电离得到 [Cr(CO), -一世*。

  DOI：

  10.1021/ja00247a015
• 作为产物：
  描述：

  2'-脱氧胞嘧啶核苷 生成 d(C6)
  参考文献：
  名称：

  Oligodeoxynucleotides containing unnatural L-2′-deoxyribose

  摘要：

  The synthesis and properties of oligonucleotides containing L-2'-dC and L-2'-dU are reported.

  DOI：

  10.1016/s0040-4039(00)78788-0

文献信息

• Nucleotides, Part LXV, Synthesis of 2′-Deoxyribonucleoside 5′-Phosphoramidites: New Building Blocks for the Inverse (5′-3′)-Oligonucleotide Approach
  作者：Thomas Wagner、Wolfgang Pfleiderer

  DOI：10.1002/1522-2675(20000809)83:8<2023::aid-hlca2023>3.0.co;2-p

  日期：2000.8.9

  The syntheses of the 3'-O-(4,4'-dimethoxytrityl)-protected 5'-phosphoramidites 25-28 and 5'-(hydrogen succinates) 29-32, which can be used as monomeric building blocks for the inverse (5'-3')-oligodeoxyribonucleotide synthesis are described (Scheme). These activated nucleosides and nucleotides were obtained by two slightly different four-step syntheses starting with the base-protected nucleosides 13-20. For the protection of the aglycon residues, the well-established 2-(4-nitrophenyl)ethyl (npe) and [2-(4-nitrophenyl)ethoxy]carbonyl (npeoc) groups were used. The assembly of the oligonucleotides required a slightly increased coupling time of 3 min in application of the common protocol (see Table 1). The use of pyridinium hydrochloride as an activator (instead of 1H-tetrazole) resulted in an extremely shorter activation time of 30 seconds. We established the efficiency of this inverse strategy by the synthesis of the oligonucleotide 3'-conjugates 33 and 34 which carry lipophilic caps derived from cholesterol and vitamin E, respectively, as well as by the formation of (3'-3')- and (5'-5')-internucleotide linkages (see Table 2).