(4-Nitrophenyl)-(11-phenyl-6,11-dihydrobenzo[c][1]benzazepin-5-yl)methanone | 226077-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (4-Nitrophenyl)-(11-phenyl-6,11-dihydrobenzo[c][1]benzazepin-5-yl)methanone
• CAS: 226077-15-2
• 化学式: C₂₇H₂₀N₂O₃
• 分子量: 420.467
• InChiKey: JABOSEYKEDBRSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-硝基苯甲酰氯 、 11-phenyl-5,6-dihydro-11H-dibenz[b,e]azepine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (4-Nitrophenyl)-(11-phenyl-6,11-dihydrobenzo[c][1]benzazepin-5-yl)methanone
  参考文献：
  名称：

  11-Phenyl-[b,e]-dibenzazepine compounds: Novel antitumor agents

  摘要：

  A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.001

文献信息

• SUBSTITUTED 11-PHENYL-DIBENZAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OR PREVENTION OF DISEASES CHARACTERIZED BY ABNORMAL CELL PROLIFERATION
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：EP1047676B1

  公开（公告）日：2007-06-27
• 11-Phenyl-[b,e]-dibenzazepine compounds: Novel antitumor agents
  作者：Raed A. Al-Qawasmeh、Yoon Lee、Ming-Yu Cao、Xiaoping Gu、Stéphane Viau、Jeff Lightfoot、Jim A. Wright、Aiping H. Young

  DOI：10.1016/j.bmcl.2008.11.001

  日期：2009.1

  A series of 11-phenyl-[b,e]-dibenzazepine compounds were synthesized and shown to be inhibitors of tumor cell proliferation with IC50 values ranging from submicromolar to micromolar concentrations. Flow cytometric analyses of several active compounds demonstrated inhibition of cell cycle progression at the G(0)-G(1) phase transition resulting in G(0)-G(1) arrest. (C) 2008 Elsevier Ltd. All rights reserved.