3,4-diphenyl-1-(pyridin-2-yl)-5,6,7,8-tetrahydroisoquinoline | 1443987-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,4-diphenyl-1-(pyridin-2-yl)-5,6,7,8-tetrahydroisoquinoline
• CAS: 1443987-46-9
• 化学式: C₂₆H₂₂N₂
• 分子量: 362.474
• InChiKey: GELKYVGCRKJVOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.36
• 重原子数：
  28.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  25.78
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3,4-diphenyl-1-(pyridin-2-yl)-5,6,7,8-tetrahydroisoquinoline 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 邻二甲苯 为溶剂， 反应 10.0h， 以68%的产率得到3,4-diphenyl-1-(2-pyridyl)isoquinoline
  参考文献：
  名称：

  A rational protocol for the synthesis of 1-(2-pyridyl)isoquinolines

  摘要：

  Aza-Diels-Alder reaction between 3-(2-pyridyl)-1,2,4-triazines and 1-morpholinocyclohexene followed by aromatization of the cyclohexene moiety affords 1-(2-pyridyl)isoquinolines. Crystal structures of two tetrahydroisoquinolines were confirmed by X-ray diffraction analysis.

  DOI：

  10.1016/j.mencom.2013.05.007
• 作为产物：
  描述：

  1-吗啉基-1-环己烯 、 3-(2-吡啶基)-5,6-二苯基-1,2,4-三嗪 以 neat (no solvent) 为溶剂， 反应 4.0h， 以54%的产率得到3,4-diphenyl-1-(pyridin-2-yl)-5,6,7,8-tetrahydroisoquinoline
  参考文献：
  名称：

  A rational protocol for the synthesis of 1-(2-pyridyl)isoquinolines

  摘要：

  Aza-Diels-Alder reaction between 3-(2-pyridyl)-1,2,4-triazines and 1-morpholinocyclohexene followed by aromatization of the cyclohexene moiety affords 1-(2-pyridyl)isoquinolines. Crystal structures of two tetrahydroisoquinolines were confirmed by X-ray diffraction analysis.

  DOI：

  10.1016/j.mencom.2013.05.007

文献信息

• Synthesis and characterizations of new cadmium complexes based on poly(aza)arene-annelated 2,2′-bipyridines
  作者：Dmitry S. Kopchuk、Pavel A. Slepukhin、Igor S. Kovalev、Albert F. Khasanov、Olga S. Taniya、Olga V. Shabunina、Grigory V. Zyryanov、Vladimir L. Rusinov、Oleg N. Chupakhin

  DOI：10.1016/j.poly.2016.02.047

  日期：2016.5

  We have developed an efficient synthesis of new cadmium(II)-containing complexes based on poly(aza) arene-annelated 2,2'-bipyridines. All the complexes were characterized by X-ray structural analysis. The influence of the type of the ligand at the structural properties of the complexes has been studied. (C) 2016 Elsevier Ltd. All rights reserved.