1H-Indene-1-butanamine, 2,3-dihydro-6-(phenylmethyl)- | 193819-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: 1H-Indene-1-butanamine, 2,3-dihydro-6-(phenylmethyl)-
• 英文别名: 4-(6-benzyl-2,3-dihydro-1H-inden-1-yl)butan-1-amine
• CAS: 193819-38-4
• 化学式: C₂₀H₂₅N
• 分子量: 279.4
• InChiKey: CFXFIKUJAHECFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Human skin equivalents expressing exogenous polypeptides
  申请人：Stratatech Corporation

  公开号：EP2481287A1

  公开（公告）日：2012-08-01

  The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

  本发明一般涉及用于伤口闭合的组合物。更具体地说，本发明提供了工程化表达外源多肽（如抗菌多肽和角质细胞生长因子2）的人皮等效物，以及制造工程化表达外源多肽的人皮等效物的组合物和方法。此外，本发明还提供了用工程化表达外源多肽的人体皮肤等效物治疗伤口的方法。
• METHODS FOR PROVIDING HUMAN SKIN EQUIVALENTS
  申请人：Stratatech Corporation

  公开号：EP3473102A1

  公开（公告）日：2019-04-24

  The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compositions and methods for making human skin equivalents engineered to express exogenous polypeptides. In addition, the present invention provides methods for treatment of wounds with human skin equivalents engineered to express exogenous polypeptides.

  本发明一般涉及用于伤口闭合的组合物。更具体地说，本发明提供了工程化表达外源多肽（如抗菌多肽和角质细胞生长因子2）的人皮等效物，以及制造工程化表达外源多肽的人皮等效物的组合物和方法。此外，本发明还提供了用工程化表达外源多肽的人体皮肤等效物治疗伤口的方法。
• Methods and compositions for wound healing
  申请人：IMBED BIOSCIENCES, INC.

  公开号：US10940120B2

  公开（公告）日：2021-03-09

  The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polymers to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.

  本发明涉及伤口愈合的方法和组合物。特别是，本发明涉及利用交联剂共价修饰分子将伤口活性剂附着和输送到伤口，从而促进和增强伤口愈合。此外，本发明还提供了利用带相反电荷的聚合物在伤口表面形成聚电解质层的方法和组合物。本发明还涉及将伤口活性剂掺入聚电解质层以输送到伤口。
• Methods and compositions for modifying mucous membranes
  申请人：Abbott Nicholas L.

  公开号：US10966935B2

  公开（公告）日：2021-04-06

  The present invention relates to methods and compositions for modifying mucous membranes. In particular, the present invention relates to treating diseases associated with mucous membranes by changing the intrinsic chemical composition and/or physical features of a target mucous membrane.

  本发明涉及改变粘膜的方法和组合物。特别是，本发明涉及通过改变目标粘膜的内在化学成分和/或物理特征来治疗与粘膜有关的疾病。
• Transplant media
  申请人：——

  公开号：US20020090369A1

  公开（公告）日：2002-07-11

  The present invention relates to media containing purified antimicrobial polypeptides, such as defensins, and/or cell surface receptor binding proteins. The media may also contain buffers, macromolecular oncotic agents, energy sources, impermeant anions, ATP substrates. The media find use for the storage and preservation of internal organs prior to transplant.

  本发明涉及含有纯化的抗菌多肽（如防御素）和/或细胞表面受体结合蛋白的培养基。培养基还可含有缓冲剂、大分子抗肿瘤剂、能量源、抗渗阴离子、ATP 底物。这种培养基可用于储存和保存移植前的内脏器官。