2-(methacryloyloxy)ethyl 6-chloro-7-hydroxycoumarin-3-carboxylate | 1218788-32-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 2-(methacryloyloxy)ethyl 6-chloro-7-hydroxycoumarin-3-carboxylate
• CAS: 1218788-32-9
• 化学式: C₁₆H₁₃ClO₇
• 分子量: 352.728
• InChiKey: WSCKJFXWAZBVMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.43
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  103.04
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  2,4-二羟基苯甲醛 在 哌啶 、 sodium hypochlorite 、 五氯化磷 、 硫酸 、 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 88.5h， 生成 2-(methacryloyloxy)ethyl 6-chloro-7-hydroxycoumarin-3-carboxylate
  参考文献：
  名称：

  Photodegradable Hydrogels to Generate Positive and Negative Features over Multiple Length Scales

  摘要：

  Here we present a photodegradable hydrogel as a biocompatible, nonfouling photoresist capable of presenting positive and negative features through single-photon and two-photon degradation. All ortho-nitrobenzylether (o-NBE) moiety is used as a polymerizable cap for poly(ethylene glycol) chains to create a photodegradable macromer. Positive and negative features can be patterned into/onto a hydrogel over a broad range of length scales (similar to 10(-7) to 10(-2) in (nm-cm)) in single- and two-photon photolysis. Phase contrast micrographs and profilometry data show that a partially degradable hydrogel network undergoes swelling to produce positive features with varying size (10-100 mu m). Conjugation of a coumarin fluorophore to the o-NBE macromer enhances the sensitivity of the hydrogel to two-photon degradation, simultaneously incorporating fluorescence visualization with no added dye.

  DOI：

  10.1021/ma9023679