3-((Z)-2-Acetylamino-2-phenylcarbamoyl-vinyl)-4,6-dichloro-indole-1,2-dicarboxylic acid 2-allyl ester 1-tert-butyl ester | 245510-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-((Z)-2-Acetylamino-2-phenylcarbamoyl-vinyl)-4,6-dichloro-indole-1,2-dicarboxylic acid 2-allyl ester 1-tert-butyl ester
• CAS: 245510-58-1
• 化学式: C₂₈H₂₇Cl₂N₃O₆
• 分子量: 572.445
• InChiKey: GQQDGUWPQXFJDG-QNGOZBTKSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  3-((Z)-2-Acetylamino-2-phenylcarbamoyl-vinyl)-4,6-dichloro-indole-1,2-dicarboxylic acid 2-allyl ester 1-tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以60%的产率得到3-((Z)-2-Acetylamino-2-phenylcarbamoyl-vinyl)-4,6-dichloro-1H-indole-2-carboxylic acid allyl ester
  参考文献：
  名称：

  Substituted Indole-2-carboxylates as Potent Antagonists of the Glycine Binding Site Associated with the NMDA Receptor

  摘要：

  A novel series of indole-2-carboxylate analogues of GV 150526 (1) in which the propenoic double bond was substituted with different "probes" or replaced by a isosteric cyclopropyl moiety were synthesized and evaluated for their affinity profile in order to obtain further information on the pharmacophoric model of the glycine binding site associated to the NMDA receptor.

  DOI：

  10.1002/(sici)1521-4184(19998)332:8<271::aid-ardp271>3.0.co;2-x
• 作为产物：
  描述：

  (Acetylamino-phenylcarbamoyl-methyl)-phosphonic acid dimethyl ester 、 4,6-Dichloro-3-formyl-indole-1,2-dicarboxylic acid 2-allyl ester 1-tert-butyl ester 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以52%的产率得到3-((Z)-2-Acetylamino-2-phenylcarbamoyl-vinyl)-4,6-dichloro-indole-1,2-dicarboxylic acid 2-allyl ester 1-tert-butyl ester
  参考文献：
  名称：

  Substituted Indole-2-carboxylates as Potent Antagonists of the Glycine Binding Site Associated with the NMDA Receptor

  摘要：

  A novel series of indole-2-carboxylate analogues of GV 150526 (1) in which the propenoic double bond was substituted with different "probes" or replaced by a isosteric cyclopropyl moiety were synthesized and evaluated for their affinity profile in order to obtain further information on the pharmacophoric model of the glycine binding site associated to the NMDA receptor.

  DOI：

  10.1002/(sici)1521-4184(19998)332:8<271::aid-ardp271>3.0.co;2-x