2-(4-{4-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N-methyl-propionamide | 476010-90-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-{4-[3-(5-tert-Butyl-3-methanesulfonylamino-2-methoxy-phenyl)-ureido]-naphthalen-1-yloxy}-pyrimidin-2-ylamino)-N-methyl-propionamide
• 英文别名: 2-[[4-[4-[[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]carbamoylamino]naphthalen-1-yl]oxypyrimidin-2-yl]amino]-N-methylpropanamide
• CAS: 476010-90-9
• 化学式: C₃₁H₃₇N₇O₆S
• 分子量: 635.744
• InChiKey: MTFBTUFCKOIVHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  45
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  181
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• Compounds useful as anti-inflammatory agents
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030008868A1

  公开（公告）日：2003-01-09

  Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

  公开了一些化合物，可用于制备用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病的药物组合物。还公开了制备这些化合物的方法。
• DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1392661A1

  公开（公告）日：2004-03-03
• US6852717B2
  申请人：——

  公开号：US6852717B2

  公开（公告）日：2005-02-08
• [EN] DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS<br/>[FR] DERIVES DE DIARYLUREE UTILISABLES EN TANT QU'AGENTS ANTI-INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002092576A1

  公开（公告）日：2002-11-21

  Disclosed are diarylurea derivatives useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.