3-tert-butoxycarbonylamino-5-hydroxymethyl-thiophene-2-carboxylic acid methyl ester | 946605-40-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-tert-butoxycarbonylamino-5-hydroxymethyl-thiophene-2-carboxylic acid methyl ester
• 英文别名: methyl 5-(hydroxymethyl)-3-[(2-methylpropan-2-yl)oxycarbonylamino]thiophene-2-carboxylate
• CAS: 946605-40-9
• 化学式: C₁₂H₁₇NO₅S
• 分子量: 287.337
• InChiKey: BGTYJVNIZNHKDJ-UHFFFAOYSA-N

物化性质

• 沸点：
  396.7±42.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-tert-butoxycarbonylamino-5-hydroxymethyl-thiophene-2-carboxylic acid methyl ester 、 叔丁基二苯基氯硅烷 在 4-二甲氨基吡啶 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 3-tert-butoxycarbonylamino-5-(tert-butyl-diphenyl-silanyloxymethyl)-thiophene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  WO2007/93363

  摘要：

  公开号：
• 作为产物：
  描述：

  methyl 3-[(tert-butoxycarbonyl)amino]-5-formylthiophene-2-carboxylate 在 sodium tetrahydroborate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 3-tert-butoxycarbonylamino-5-hydroxymethyl-thiophene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  WO2007/93363

  摘要：

  公开号：

文献信息

• NOVEL AMINO ALCOHOL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090076002A1

  公开（公告）日：2009-03-19

  The invention relates to amino alcohol-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.

  本发明涉及氨基醇取代的芳基噻唑嘧啶酮及其衍生物、其生理上可耐受的盐和生理功能衍生物、其制备方法、包含本发明中至少一种氨基醇取代的芳基噻唑嘧啶酮或其衍生物的药物以及将本发明中的氨基醇取代的芳基噻唑嘧啶酮及其衍生物用作MCH拮抗剂的用途。
• NOVEL AZACYCLYL-SUBSTITUTED ARYLTHIENOPYRIMIDINONES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：SCHWINK Lothar

  公开号：US20090082339A1

  公开（公告）日：2009-03-26

  The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.

  本发明涉及氮杂环取代芳基噻唑嘧啶酮及其衍生物、其生理上耐受的盐和生理上功能性衍生物、其制备方法、包含本发明中至少一种氮杂环取代芳基噻唑嘧啶酮或其衍生物的药物以及将本发明中的氮杂环取代芳基噻唑嘧啶酮及其衍生物用作MCH拮抗剂的用途。
• Amino alcohol-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
  申请人：Schwink Lothar

  公开号：US08853208B2

  公开（公告）日：2014-10-07

  The invention relates to amino alcohol-substituted arylthienopyrimidinones having a formula I and their derivatives, and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one amino alcohol-substituted arylthienopyrimidinone of the invention or its derivative, and the use of the amino alcohol-substituted arylthienopyrimidinones of the invention and their derivatives as MCH antagonists.

  本发明涉及具有公式I及其衍生物的氨基醇取代芳基噻唑嘧啶酮，以及它们的生理耐受盐和生理功能衍生物、它们的制备方法、包含本发明中至少一种氨基醇取代芳基噻唑嘧啶酮或其衍生物的药物，以及将本发明中的氨基醇取代芳基噻唑嘧啶酮及其衍生物作为MCH拮抗剂的用途。
• Azacyclyl-substituted arylthienopyrimidinones, process for their preparation and their use as medicaments
  申请人：Schwink Lothar

  公开号：US08828991B2

  公开（公告）日：2014-09-09

  The invention relates to azacyclyl-substituted arylthienopyrimidinones and their derivatives, of the Formula (I); and their physiologically tolerated salts and physiologically functional derivatives, their preparation, medicaments comprising at least one azacyclyl-substituted arylthienopyrimidinone according to Formula (I) or its derivative, and the use of the azacyclyl-substituted arylthienopyrimidinones according to Formula (I) and their derivatives as MCH antagonists.

  该发明涉及一种含有氮杂环取代的芳基噻唑嘧啶酮及其衍生物，其化学式为(I)；及其生理上可耐受的盐和生理上功能性衍生物，其制备方法，包含至少一种符合化学式(I)或其衍生物的氮杂环取代的芳基噻唑嘧啶酮的药物，以及将符合化学式(I)及其衍生物的氮杂环取代的芳基噻唑嘧啶酮用作MCH受体拮抗剂的用途。
• WO2007/93365
  申请人：——

  公开号：——

  公开（公告）日：——