L-Glutamic acid, N-(1-oxopropyl)- | 66320-36-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Glutamic acid, N-(1-oxopropyl)-
• 英文别名: (2S)-2-(propanoylamino)pentanedioic acid
• CAS: 66320-36-3
• 化学式: C₈H₁₃NO₅
• 分子量: 203.19
• InChiKey: DKKGGIHZVKOAPK-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Charged sophorolipids and sophorolipid containing compounds
  申请人：Zerkowski Jonathan

  公开号：US20070027106A1

  公开（公告）日：2007-02-01

  A sophorolid produced by a method involving reacting a compound of formula I with a compound of formula II wherein R 1 and R 2 are H, C 1 -C 18 alkyl, C 3 -C 18 alkenyl, C 3 -C 10 cycloalkyl, phenyl, or C 1 through C 18 acyl or alkoxycarbonyl, R 1 and R 2 are not both acyl, R 3 is H, CH 3 , CH 2 -phenyl, CH 2 —C 6 H 4 —OH, CH 2 CO 2 H, CH 2 CH 2 CO 2 H, CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 OH, CH(CH 3 )OH, CH 2 CH 2 CH 2 CH 2 NH 2 , CH 2 CH 2 CONH 2 , CH 2 CONH 2 , CH 2 —C 3 N 2 H 3 (histidine), CH 2 CH 2 CH 2 NHC(NH)NH 2 , CH 2 CH 2 SCH 3 , R 2 and R 3 may be joined in a ring, R 4 is H, C 1 -C 18 alkyl, C 3 -C 18 alkenyl, C 3 -C 10 cycloalkyl, or phenyl, n is 0-6, R 5 and R 6 are H, C 1 -C 18 alkyl, C 3 -C 18 alkenyl, C 3 -C 10 cycloalkyl, or phenyl, and X is C 1 -C 18 alkyl or C 1 -C 18 alkenyl; optionally followed by acidolytic (treating with an acid) or hydrogenolytic deprotection (treating with a hydrogenolysis catalyst) which removes one of the groups R 1 or R 2 and replaces it with hydrogen. Also a sophorolipid containing composition containing a carrier and at least one sophorolipid described above.

  通过一种涉及将式I化合物与式II化合物反应的方法生产的一种索福罗脂，其中R1和R2为H、C1-C18烷基、C3-C18烯基、C3-C10环烷基、苯基或C1-C18酰基或烷氧羰基，R1和R2不同时为酰基，R3为H、CH3、CH2-苯基、CH2—C6H4—OH、CH2CO2H、CH2CH2CO2H、CH(CH3)2、CH2CH(CH3)2、CH(CH3)CH2CH3、CH2OH、CH(CH3)OH、CH2CH2CH2CH2NH2、CH2CH2CONH2、CH2CONH2、CH2—C3N2H3（组氨酸）、CH2CH2CH2NHC(NH)NH2、CH2CH2SCH3，R2和R3可连接成环，R4为H、C1-C18烷基、C3-C18烯基、C3-C10环烷基或苯基，n为0-6，R5和R6为H、C1-C18烷基、C3-C18烯基、C3-C10环烷基或苯基，X为C1-C18烷基或C1-C18烯基；可选择性地接着酸解（用酸处理）或氢解保护（用氢解催化剂处理），去除R1或R2中的一个基团，并用氢替换之。还有一种含有载体和上述至少一种索福罗脂的索福罗脂含有组合物。
• Platinum(II) complexes of N-substituted amino dicarboxylates and the preparation method thereof
  申请人：Board of Trustees, EWHA Womans University

  公开号：US20040162342A1

  公开（公告）日：2004-08-19

  Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof: 1 wherein n is 1 or 2; A-A is a diamine selected from the group consisting of trans-(±)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and R 1 is hydrogen and R 2 is RCO or RSO 2 , wherein R is an alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or R 1 R 2 is phthaloyl.

  揭示了一种具有抗肿瘤活性的N-取代氨基二羧酸盐的铂（II）配合物，其化学式如下（1），以及其制备方法：其中n为1或2；A-A是从反式（±）-1,2-二氨基环己烷，乙二胺和2,2-二甲基-1,3-丙二胺组成的二胺；R1为氢，R2为RCO或RSO2，其中R为从甲基、乙基、正丙基、正丁基和叔丁基中选择的烷基，或从苯基和取代苯基组成的芳基，或R1R2为邻苯二甲酰。
• [EN] PLATINUM(II) COMPLEXES OF N-SUBSTITUTED AMINO DICARBOXYLATES AND THE PREPARATION METHOD THEREOF<br/>[FR] COMPLEXES PLATINE (II) D'AMINO DICARBOXYLATES SUBSTITUES EN N ET PROCEDE DE FABRICATION
  申请人：TRUSTEES EWHA WOMANS UNIVERSIT

  公开号：WO2004074299A1

  公开（公告）日：2004-09-02

  Disclosed are a platinum (II) complex of N-substituted amino dicarboxylate showing antitumor activity represented by the following formula (1) and a preparation method thereof: (I) wherein n is 1 or 2; A-A is a diamine selected from the group consisting of trans-(±)-1,2-diaminocyclohexane, ethylenediamine and 2,2-dimethyl-1,3-propanediamine; and R1 is hydrogen and R2 is RCO or RS02, wherein R is an to alkyl selected from the group consisting of methyl, ethyl, n-propyl, n-butyl and t-butyl or an aryl selected from the group consisting of phenyl and substituted phenyl group, or R1R2 is phthaloyl.

  揭示了一种具有抗肿瘤活性的N-取代氨基二羧酸铂（II）配合物，其化学式如下所示（1），以及其制备方法：（I）其中n为1或2；A-A是从反式-（±）-1,2-二氨基环己烷、乙二胺和2,2-二甲基-1,3-丙二胺中选择的二胺；R1为氢，R2为RCO或RSO2，其中R是从甲基、乙基、正丙基、正丁基和叔丁基中选择的烷基或从苯基和取代苯基组成的芳基，或者R1R2为邻苯二甲酰基。
• Cosmestic composition
  申请人：UNILEVER PLC

  公开号：EP0572167A1

  公开（公告）日：1993-12-01

  A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamic acid derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

  一种适用于哺乳动物皮肤和毛发的外用组合物，可诱导、维持或增加毛发生长，其中包括一种毛发生长促进剂，选自谷氨酸衍生物及其盐类。该组合物最好还包含一种活性增强剂，它可以选自毛发生长刺激剂、渗透增强剂和阳离子聚合物。
• Molecularly imprinted polymer for selectively trapping odorous molecules
  申请人：L'ORÉAL

  公开号：US10772823B2

  公开（公告）日：2020-09-15

  The invention relates to the use of molecularly imprinted polymer(s) or MIPs, of odorous molecule(s), as deodorant agent in particular for selectively trapping molecules that are the cause of human body odour. More particularly by using MIPs which may be obtained via polymerization, preferably via radical polymerization, of a mixture of: i) optionally one or more polymerization initiator(s); ii) one or more functional monomer(s); iii) one or more crosslinking agent(s); and iv) one or more porogenic solvent(s); it being understood that the polymerization a) or b) is performed in the presence v) of one or more “templates” of target molecule(s) responsible for human body odour. Another subject of the invention concerns a process for preparing MIPs as defined previously, MIPs obtained via this process, and a cosmetic composition comprising at least one MIP as defined previously. Unexpectedly, it appears that the MIPs make it possible to specifically trap precursors of odorous molecules and odorous molecules that may be used in cosmetic formulations, especially those that are the cause of the unpleasant odour of sweat.

  本发明涉及气味分子的分子印迹聚合物或 MIPs 作为除臭剂的用途，特别是用于选择性地捕获导致人体气味的分子。更具体地说，MIPs 可通过以下混合物的聚合（最好是自由基聚合）获得：i) 一种或多种聚合引发剂；ii) 一种或多种功能性单体；iii) 一种或多种交联剂；iv) 一种或多种致孔溶剂。本发明的另一个主题涉及前文定义的 MIP 制备工艺、通过该工艺获得的 MIP 以及包含至少一种前文定义的 MIP 的化妆品组合物。令人意想不到的是，MIPs 似乎可以专门捕获气味分子的前体和可用于化妆品配方的气味分子，特别是那些导致难闻汗味的分子。