| 866403-06-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 866403-06-7
• 化学式: C₁₂₀H₁₀₄N₁₆O₁₆Pt
• 分子量: 2221.32
• InChiKey: WWMYJOAMRHYVCP-MBRGXXNDSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  14.44
• 重原子数：
  153.0
• 可旋转键数：
  24.0
• 环数：
  25.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  420.58
• 氢给体数：
  8.0
• 氢受体数：
  22.0

反应信息

• 作为产物：
  描述：

  10-Oxo-2,3,5,6-tetrahydro-1H,4H,10H-11-oxa-3a-aza-benzo[de]anthracene-9-carboxylic acid (2-amino-ethyl)-amide 、 在 N-甲基吗啉 、 2-chloro-4,6-dimethoxytriazine 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以61%的产率得到
  参考文献：
  名称：

  Phosphorescent Oxygen Sensor with Dendritic Protection and Two-Photon Absorbing Antenna

  摘要：

  Imaging oxygen in 3D with submicron spatial resolution can be made possible by combining phosphorescence quenching technique with multiphoton laser scanning microscopy. Because Pt and Pd porphyrin-based phosphorescent dyes, traditionally used as phosphors in biological oxygen measurements, exhibit extremely low two-photon absorption (2PA) cross-sections, we designed a nanosensor for oxygen, in which a 2P absorbing antenna is coupled to a metalloporphyrin core via intramolecular energy transfer (ET) with the purpose of amplifying the 2PA induced phosphorescence of the metalloporphyrin. The central component of the device is a polyfunctionalized Pt porphyrin, whose triplet state emission at ambient temperatures is strong, occurs in the near infrared and is sensitive to O-2. The 2PA chromophores are chosen in such a way that their absorption is maximal in the near infrared (NIR) window of tissue (e.g., 700-900 nm), while their fluorescence is overlapped with the absorption band(s) of the core metalloporphyrin, ensuring an efficient antenna-core resonance ET. The metalloporphyrin-antenna construct is embedded inside the protecting dendritic jacket, which isolates the core from interactions with biological macromolecules, controls diffusion of oxygen and makes the entire sensor water-soluble. Several Pt porphyrin-cournarin based sensors were synthesized and their photophyics studied to evaluate the proposed design.

  DOI：

  10.1021/ja052947c