(E)-6-methyl-4,4-diphenyl-2,6-heptadien-1-ol | 155934-17-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-6-methyl-4,4-diphenyl-2,6-heptadien-1-ol
• CAS: 155934-17-1
• 化学式: C₂₀H₂₂O
• 分子量: 278.394
• InChiKey: YISCCQRLKZBEBU-NTEUORMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.49
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-6-methyl-4,4-diphenyl-2,6-heptadien-1-ol 在 咪唑 、 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 双氧水 作用下， 反应 8.0h， 生成 (E)-2-methyl-7-dimethylthexylsilyloxy-4,4-diphenyl-5-hepten-1-ol
  参考文献：
  名称：

  Fused Furan Construction via an Intramolecular [3+2] Cycloaddition Reaction: Syntheses of 4H-Cyclohepta- and 4H-Cyclopenta[b]furans

  摘要：

  General and efficient syntheses of 4H-cyclohepta- and 4H-cyclopenta[b]furans (4 and 5) have been accomplished employing the intramolecular [3+2] dipolar cycloaddition based fused furan construction strategy. Treatment of the oximes (20 and 29), readily prepared from the carboxylic acid (7 and 23) via a conventional sequence of reactions, with aqueous sodium hypochlorite produced excellent yields of the isoxazolines (21 and 30), which, after alkaline hydrolysis or desilylation, were exposed to the conditions of reductive hydrolysis followed by acid-catalyzed cyclization to give the corresponding fused furans (4 and 5) in good overall yields.

  DOI：

  10.3987/com-93-6623
• 作为产物：
  描述：

  4-methyl-2,2-diphenyl-4-pentenal 在 sodium hydride 、 二异丁基氢化铝 作用下， 以 甲苯 为溶剂， 反应 43.0h， 生成 (E)-6-methyl-4,4-diphenyl-2,6-heptadien-1-ol
  参考文献：
  名称：

  Fused Furan Construction via an Intramolecular [3+2] Cycloaddition Reaction: Syntheses of 4H-Cyclohepta- and 4H-Cyclopenta[b]furans

  摘要：

  General and efficient syntheses of 4H-cyclohepta- and 4H-cyclopenta[b]furans (4 and 5) have been accomplished employing the intramolecular [3+2] dipolar cycloaddition based fused furan construction strategy. Treatment of the oximes (20 and 29), readily prepared from the carboxylic acid (7 and 23) via a conventional sequence of reactions, with aqueous sodium hypochlorite produced excellent yields of the isoxazolines (21 and 30), which, after alkaline hydrolysis or desilylation, were exposed to the conditions of reductive hydrolysis followed by acid-catalyzed cyclization to give the corresponding fused furans (4 and 5) in good overall yields.

  DOI：

  10.3987/com-93-6623