硬脂酸铵 | 1002-89-7

• 物质功能分类: 无机化工 - 无机盐 - 无机铵盐
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 硬脂酸铵
• 中文别名: 十八酸铵
• 英文名称: Ammonium stearate
• 英文别名: stearic acid ammonium salt；stearic acid ; ammonium stearate；Stearinsaeure; Ammoniumstearat；Stearinsaeure; Ammonium-Verbindung；stearic acid amine；azanium;octadecanoate
• CAS: 1002-89-7
• 化学式: C₁₈H₃₆O₂*H₃N
• 分子量: 301.513
• InChiKey: JPNZKPRONVOMLL-UHFFFAOYSA-N

物化性质

• 熔点：
  21-24℃
• 沸点：
  442.62°C (rough estimate)
• 密度：
  0.8900
• 溶解度：
  微溶于H2O、苯；溶于乙醇、甲醇；不溶于丙酮
• LogP：
  8.216 (est)
• 物理描述：
  Liquid; OtherSolid
• 稳定性/保质期：
  溶于水和热的甲苯中。

计算性质

• 辛醇/水分配系数(LogP)：
  6.49
• 重原子数：
  21
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

ADMET

毒理性

• 副作用

ACGIH 致癌物 - 未分类。

ACGIH Carcinogen - Not Classifiable.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26
• 危险类别码：
  R36/37/38

SDS

---

Section 1. Chemical Product and Company Identification
Ammonium Stearate
Common Name/
Trade Name
Ammonium Stearate

---

Section 4. First Aid Measures
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least
Eye Contact
15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation occurs.
Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Skin Contact
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Not available.
Serious Inhalation
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Not available.
Serious Ingestion

---

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Not available.
Flammable Limits
These products are carbon oxides (CO, CO2).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards in
Risks of explosion of the product in presence of static discharge: Not available.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Not available.
Special Remarks on
Fire Hazards
Not available.
Special Remarks on
Explosion Hazards

---

Section 6. Accidental Release Measures
Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading
Small Spill
water on the contaminated surface and dispose of according to local and regional authority requirements.
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on
Large Spill
the contaminated surface and allow to evacuate through the sanitary system.
Ammonium Stearate

---

Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. G round all equipment containing material. Do not
Precautions
breathe dust.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage

---

Section 8. Exposure Controls/Personal Protection
Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering Controls
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Gloves (impervious). In well ventilated areas or if used in a fume hood, respiratory
protection is not normally required.
Personal Protection in Case Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a specialist
of a Large Spill BEFORE handling this product.
Not available.
Exposure Limits

---

Section 9. Physical and Chemical Properties
Solid. (Paste) Not available.
Physical state and O dor
appearance
Not available.
Taste
301.52 g/mole
Molecular Weight
White to yellowish.
Color
Not available.
pH (1% soln/water)
Not available.
Boiling Point
Not available.
Melting Point
Not available.
Critical Temperature
1.01 (Water = 1)
Specific Gravity
Not applicable.
Vapor Pressure
Not available.
Vapor Density
Not available.
Volatility
Not available.
Odor Threshold
Not available.
Water/Oil Dist. Coeff.
Not available.
Ionicity (in Water)
Not available.
Dispersion Properties
Very slightly soluble in cold water.
Solubility

---

Section 10. Stability and Reactivity Data
The product is stable.
Stability
Not available.
Instability Temperature
Conditions of Instability Excess heat, incompatible materials
Incompatibility with various Not available.
substances
Not available.
Corrosivity
Ammonium Stearate
Not available.
Special Remarks on
Reactivity
Not available.
Special Remarks on
Corrosivity
Will not occur.
Polymerization

---

Section 11. Toxicological Information
Ingestion.
Routes of Entry
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion.
Non-hazardous in case of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Not available.
Special Remarks on
Chronic Effects on Humans
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: Not considered an inhalation hazard since it is in paste form.
Ingestion: Expected to be a low hazard.

---

Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
The product itself and its products of degradation are not toxic.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation

---

Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental control
regulations.

---

Section 14. Transport Information
Not a DOT controlled material (United States).
DO T Cl assi fi cati on
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
Ammonium Stearate
DO T (Pi ctograms)

---

Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Ammonium Stearate
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has found to
California
cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: No products were found.
Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No.
213-695-2).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Listed on National Inventory.
Japan: Listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
This product is not classified according Not applicable.
DSCL (EEC)
to the EU regulations.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity 0
Specific hazard
Personal Protection
B
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG(Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves (impervious).
Ammonium Stearate
Lab coat.
Not applicable.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

硬脂酸铵概述

硬脂酸铵在热水中分散，能溶于热甲苯，微溶于乙醇和热醋酸丁酯。加热至110℃前会分解。它与强酸作用生成硬脂酸和相应的铵盐。该物质由熔融的硬脂酸与氢氧化铵反应制得。硬脂酸铵可用作分散剂、乳化剂及增稠剂，也可用作混凝土和水泥等材料的防水成分。

制备

1. 在反应容器中依次加入配方量的硬脂酸、十二烷基硫酸钠和水，并调温至10-25℃，搅拌均匀后，逐步加入氨水。调节搅拌速度至1200-1600转/分，直至硬脂酸完全融化并形成具有流动性的硬脂酸铵液体；

2. 将步骤1制得的硬脂酸铵液体吸入乳化罐中，在乳化机以2600-3200转/分的速度进行乳化，直至液体颜色变为银白色金属光泽且黏度≤350cps。静置1-2小时后过滤，即得到硬脂酸铵乳液。

用途

硬脂酸铵可用作乳化剂、分散剂、湿润剂和防湿剂等。

类别

有毒物品

毒性分级

中毒

可燃性危险特性

可燃；受热产生有毒氮氧化物和氨烟雾

储运特性

库房需通风干燥，低温保存

灭火剂

干粉、泡沫、砂土、二氧化碳及雾状水

职业标准

TWA 10 毫克/立方米

反应信息

• 作为反应物：
  描述：

  硬脂酸铵 生成 氨
  参考文献：
  名称：

  Falciola, Gazzetta Chimica Italiana, 1910, vol. 40 II, p. 219

  摘要：

  DOI：
• 作为产物：
  描述：

  硬脂酸 、 氨 、 oxidanium;octadecanoate 以 水 为溶剂， 以to obtain an aqueous dispersion of ammonium stearate having a solid content of 20%的产率得到硬脂酸铵
  参考文献：
  名称：

  Binder for inorganic fiber and heat insulating acoustic inorganic fiber material

  摘要：

  一种用于无机纤维的粘合剂，包括可缩聚的醛类热固性树脂前体和具有聚氟烷基团的氟碳化合物。

  公开号：

  US07019071B2

文献信息

• ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF
  申请人：Meng Charles Q.

  公开号：US20140142114A1

  公开（公告）日：2014-05-22

  The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 and X 8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

  本发明涉及以下式（I）的新型驱虫化合物： 其中 Y和Z分别是双环碳环或双环杂环基团，或者Y或Z中的一个是双环碳环或双环杂环基团，另一个是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，以及变量X 1 ，X 2 ，X 3 ，X 4 ，X 5 ，X 6 ，X 7 和X 8 如本文所定义。本发明还提供了包含本发明的驱虫化合物的兽药组合物，以及它们用于治疗和预防动物寄生虫感染的用途。
• [EN] ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS<br/>[FR] COMPOSÉS DEPSIPEPTIDIQUES ANTHELMINTHIQUES
  申请人：MERIAL INC

  公开号：WO2018093920A1

  公开（公告）日：2018-05-24

  The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

  本发明提供了公式（I）的环状脱氨肽化合物，其中至少一个碳原子的立体化学构型与自然存在的环状脱氨肽PF1022A的基团Cy1、Cy2、R1、R2、R3、R4、Ra和Rb相比发生了倒置。该发明还提供了包含这些化合物的组合物，对危害动物的寄生虫具有有效性。这些化合物和组合物可用于对抗哺乳动物和鸟类体内或体表的寄生虫。该发明还提供了一种改进的方法，用于根除、控制和预防鸟类和哺乳动物的寄生虫感染。
• [EN] ANTI-INFLUENZA COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS ANTI-GRIPPE ET PROCÉDÉS ASSOCIÉS
  申请人：BIOCRYST PHARM INC

  公开号：WO2014186465A1

  公开（公告）日：2014-11-20

  Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising the compounds of the invention are also described. Methods of inhibition, treatment and/or suppression of viral infections with the compounds of the invention are also described. The compositions or methods may optionally comprise one or more additional anti-viral agents.

  揭示了一种新颖的化合物，包括一种亚胺-核糖衍生物与一个碳环或杂环共价连接。还描述了包括该发明化合物的药物组合物。还描述了使用该发明化合物抑制、治疗和/或抑制病毒感染的方法。这些组合物或方法可以选择性地包括一种或多种额外的抗病毒药物。
• [EN] ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME<br/>[FR] DIHYDROAZOLES ANTIPARASITAIRES ET COMPOSITIONS LES INCLUANT
  申请人：MERIAL LTD

  公开号：WO2011075591A1

  公开（公告）日：2011-06-23

  The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

  本发明涉及式(I)的新型二氢咪唑及其盐：其中R1、A1、A2、G、X和Y如描述中所定义，以及它们的组合物、制备方法以及它们用于预防或治疗动物寄生虫感染或寄生虫侵袭以及作为杀虫剂的用途。
• D-AMPHETAMINE COMPOUNDS, COMPOSITIONS, AND PROCESSES FOR MAKING AND USING THE SAME
  申请人：KemPharm, Inc.

  公开号：US20200131130A1

  公开（公告）日：2020-04-30

  Disclosed are d-amphetamine compounds and compositions comprising at least one organic acid covalently bound to d-amphetamine, a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.

  揭示了d-安非他明化合物和组合物，其中至少有一种有机酸以共价键结合到d-安非他明，其盐，衍生物或其组合物。还公开了制备和使用这些化合物的方法。