methyl 2-allyl-3-hydroxy-5-methoxybenzoate | 68787-64-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-allyl-3-hydroxy-5-methoxybenzoate
• 英文别名: methyl 3-hydroxy-5-methoxy-2-prop-2-enylbenzoate
• CAS: 68787-64-4
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: UCKQNVAODWYVBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 2-allyl-3-hydroxy-5-methoxybenzoate 在 一氯化碘 作用下， 以 四氯化碳 为溶剂， 以82%的产率得到3,4-dihydro-5-hydroxy-3-iodomethyl-7-methoxy-1H-2-benzopyran-1-one
  参考文献：
  名称：

  Occelli, Emilio; DePaoli, Adele; Nathansohn, Giangiacomo, Gazzetta Chimica Italiana, 1981, vol. 111, # 9/10, p. 383 - 390

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 3-(allyloxy)-5-methoxybenzoate 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以72%的产率得到methyl 2-allyl-3-hydroxy-5-methoxybenzoate
  参考文献：
  名称：

  4-메톡시-2-펜에틸이소인돌린-1-온 유도체 및 이를 포함하는 신경질환의 치료용 조성물

  摘要：

  本发明涉及一种新的4-甲氧基-2-乙基异吲哚啉-1-酮诱导剂化合物，具有促进神经生长因子增加，促进神经细胞生长和抗神经炎活性，以及包含该化合物的用于预防，改善和治疗神经疾病的组合物。

  公开号：

  KR20220040291A

文献信息

• 2,4,6-Trisubstituted-2,3-dihydro-benzofuran derivatives
  申请人：Gruppo Lepetit S.p.A.

  公开号：US04143055A1

  公开（公告）日：1979-03-06

  New 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives of the following general formula ##STR1## wherein R is selected from hydrogen or methyl; one of R.sub.1 and R.sub.2 represents hydroxy, (C.sub.1-4)alkoxy or (C.sub.2-4)alkanoyloxy, and the other one is selected from cyano, carboxy, carbo(C.sub.1-4)alkoxy, carbamoyl and a --NR.sub.3 R.sub.4 group, wherein R.sub.3 and R.sub.4 independently represent hydrogen (C.sub.1-4)alkyl, (C.sub.2-4)alkanoyl, carbo(C.sub.1-4)alkoxy, carbobenzyloxy, carbamoyl, mono- and di-(C.sub.1-4)alkylamino-(C.sub.1-4)alkyl, benzenesulfonyl, toluenesulfonyl, (C.sub.1-4)alkylsulfonyl or phenacylsulfonyl; and salts therewith of pharmaceutically acceptable acids. The compounds have antinflammatory, analgesic and antipyretic utility.

  新的2,4,6-三取代-2,3-二氢苯并呋喃衍生物具有以下一般式##STR1##其中R从氢或甲基中选择；R.sub.1和R.sub.2中的一个代表羟基，(C.sub.1-4)烷氧基或(C.sub.2-4)烷酰氧基，另一个从氰基，羧基，羧基(C.sub.1-4)烷氧基，氨基甲酰基和--NR.sub.3 R.sub.4基中选择，其中R.sub.3和R.sub.4独立地代表氢(C.sub.1-4)烷基，(C.sub.2-4)烷酰基，羧基(C.sub.1-4)烷氧基，羧苄氧基，氨基甲酰基，单烷基胺和双(C.sub.1-4)烷基胺-(C.sub.1-4)烷基，苯磺酰基，甲苯磺酰基，(C.sub.1-4)烷基磺酰基或苯乙酰磺酰基；及其与药理学上可接受的酸盐。这些化合物具有抗炎、镇痛和退热的用途。
• FUSED PHENYL AMIDO HETEROCYCLIC COMPOUNDS
  申请人：Bai Hao

  公开号：US20080280875A1

  公开（公告）日：2008-11-13

  The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R 1 , R 1a , R 2 , R 3 , R 4 , L 2 , n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).

  本发明涉及以下式(I)的化合物：或其药用可接受的盐或溶剂，其中：环A为(4-12)成员杂环基；环B是从以下组中选择的融合苯环之一：环A、环B、环C、R1、R1a、R2、R3、R4、L2、n、t、w和z如规范中所定义。本发明还涉及包括式(I)的化合物的药物组合物以及治疗通过调节葡萄糖激酶介导的疾病的方法，该方法包括向哺乳动物施用有效量的式(I)的化合物。
• Reserpine derivatives
  申请人：Gruppo Lepetit S.p.A.

  公开号：US03978065A1

  公开（公告）日：1976-08-31

  New reserpine-like compounds of the general formula ##SPC1## Wherein R is a member of the class consisting of hydrogen, lower alkyl, lower alkenyl and acyl; R.sub.1 is selected from hydrogen and lower alkyl, and R.sub.2 is hydrogen or lower alkyl. The new reserpine-like compounds are useful anti-hypertensive agents.

  新的类似利血平的化合物的一般式为##SPC1##其中R是氢、低烷基、低烯基和酰基类的成员; R.sub.1从氢和低烷基中选择，R.sub.2是氢或低烷基。这些新的类似利血平的化合物是有用的降压剂。
• Fused Phenyl Amido Heterocyclic Compounds
  申请人：Bai Hao

  公开号：US20110039821A1

  公开（公告）日：2011-02-17

  The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: Ring A is (4-12)-membered heterocyclyl; Ring B is a fused benzene ring selected from the group consisting of: Ring A, ring B, ring C, R 1 , R 1a , R 2 , R 3 , R 4 , L 2 , n, t, w, and z are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of glucokinase, the method comprising administering to a mammal an effective amount of a compound of formula (I).

  本发明涉及以下式子的化合物(I)或其药学上可接受的盐或溶剂： 其中，环A是(4-12)成员杂环基；环B是从以下组中选择的融合苯环：环A、环B、环C、R1、R1a、R2、R3、R4、L2、n、t、w和z在规范中定义。本发明还涉及包括式(I)化合物的药物组合物和通过调节葡萄糖激酶介导的疾病的治疗方法，该方法包括向哺乳动物施用式(I)化合物的有效量。
• Total Synthesis of Isohericerinol A and Its Analogues to Access Their Potential Neurotrophic Effects
  作者：Manjunatha Vishwanath、Chhabi Lal Chaudhary、Yunjeong Park、Mayavan Viji、Chanhyun Jung、Kwanghee Lee、Jaeuk Sim、Seong Min Hong、Da Hye Yoon、Dae Hee Lee、Jae Kang Lee、Heesoon Lee、Mi Kyeong Lee、Sun Yeou Kim、Jae-Kyung Jung

  DOI：10.1021/acs.joc.2c01096

  日期：2022.8.19

  neuroprotective effects. Isohericerinol A (1), isolated by our colleagues from its fruiting parts has a strong ability to increase the nerve growth factor secretion in C6 glioma cells. The current work describes the total synthesis of 1 and its regioisomer 5 in a few steps. We present two different approaches to 1 and a regiodivergent approach for both 1 and 5 by utilizing easily accessible feedstocks

  众所周知，猴头菇的次级代谢物具有神经营养和神经保护作用。我们的同事从其果实部分分离出的异海瑞醇 A ( 1 ) 具有很强的增加 C6 神经胶质瘤细胞中神经生长因子分泌的能力。目前的工作通过几个步骤描述了1及其区域异构体5的全合成。我们通过利用容易获得的原料，为1和1和5提出了两种不同的方法和区域发散方法。有趣的是，天然产物1，区域异构体5，它们的中间体在体外实验系统中表现出强大的神经营养活性。因此，这些合成策略提供了对天然产物1进行系统的结构-活性关系研究的途径。