N,N-dimethyl-1H-benzo[d]imidazol-6-amine | 1262887-26-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N,N-dimethyl-1H-benzo[d]imidazol-6-amine
• 英文别名: 1H-Benzimidazol-6-amine, N,N-dimethyl-；N,N-dimethyl-3H-benzimidazol-5-amine
• CAS: 1262887-26-2
• 化学式: C₉H₁₁N₃
• 分子量: 161.206
• InChiKey: BIRWLKDFVCWXID-UHFFFAOYSA-N

物化性质

• 沸点：
  391.8±15.0 °C(Predicted)
• 密度：
  1.211±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  31.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲酸 、 5-二甲基氨基-2-硝基苯胺 在 铁粉 、 氯化铵 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 以89%的产率得到N,N-dimethyl-1H-benzo[d]imidazol-6-amine
  参考文献：
  名称：

  Mild and General One-Pot Reduction and Cyclization of Aromatic and Heteroaromatic 2-Nitroamines to Bicyclic 2H-Imidazoles

  摘要：

  描述了一种将芳香和杂芳香2-硝基胺转化为双环2H-苯并咪唑的一锅法步骤。该步骤采用甲酸、铁粉以及NH4Cl等添加剂来还原硝基并实现咪唑环化，通常在一到两小时内完成高产率的转化。其广泛的官能团兼容性显示了该步骤的普遍实用性。

  DOI：

  10.1055/s-0030-1259007

文献信息

• HETEROCYCLIC COMPOUNDS AND USES THEREOF
  申请人：Infinity Pharmaceuticals, Inc.

  公开号：US20150105385A1

  公开（公告）日：2015-04-16

  Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

  本文介绍了调节激酶活性的化合物和制药组合物，包括PI3激酶活性，以及与激酶活性相关的疾病和病症的化合物、制药组合物和治疗方法，包括PI3激酶活性。
• DICHLORODIKETOPYRROLOPYRROLE PIGMENT, COLORING MATERIAL DISPERSION CONTAINING THE PIGMENT, AND PROCESS FOR PRODUCTION OF THE COLORING MATERIAL DISPERSION
  申请人：FUJIFILM Corporation

  公开号：EP2471876A1

  公开（公告）日：2012-07-04

  A coloring material dispersion, having: a particle growth inhibitor; and coloring material particulates of a dichlorodiketopyrrolopyrrole pigment, said coloring material particulates having an α type crystallinity degree from 0.65 to 0.90, a crystallite size from 6.0 to 13.0 nm in a direction of a (-151) crystal face, and a crystallite size of 5.0 to 23.0 nm in a direction of a (111) crystal face.

  一种着色材料分散液，其中包含：颗粒生长抑制剂；以及二氯二酮吡咯啉颜料的着色材料颗粒，所述着色材料颗粒的 α 型结晶度为 0.65 至 0.90，沿（-151）晶面方向的结晶粒径为 6.0 至 13.0 nm，沿（111）晶面方向的结晶粒径为 5.0 至 23.0 nm。
• ULK1 inhibitors and methods using same
  申请人：SALK INSTITUTE FOR BIOLOGICAL STUDIES

  公开号：US10689397B2

  公开（公告）日：2020-06-23

  In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.

  在某些方面，本发明提供了一种治疗受试者疾病或病症的方法，该方法包括向有需要的受试者联合施用治疗有效量的至少一种ULK1抑制嘧啶和治疗有效量的mTOR抑制剂。
• ORGANIC PIGMENT FINE PARTICLES AND METHOD OF PRODUCING THE SAME, PIGMENT-DISPERSION COMPOSITION, PHOTOCURABLE COMPOSITION AND INK-JET INK CONTAINING THE SAME, AND COLOR FILTER USING THE SAME AND METHOD OF PRODUCING THE SAME
  申请人：Sasaki Daisuke

  公开号：US20100261103A1

  公开（公告）日：2010-10-14

  Organic pigment fine particles, having capability of self-dispersion, having an organic pigment and a polymer compound, the organic pigment fine particles of being nanometer-sized fine particles obtained by mixing an organic pigment solution and a second solvent, thereby to precipitate the fine particles in the mixed liquid, the organic pigment solution prepared by dissolving the organic pigment and the polymer compound in a first solvent, the second solvent of being served as a poor solvent for the organic pigment and being compatible with the first solvent, in which a compound insoluble in the second solvent is used as the polymer compound, and the organic pigment fine particles are provided with a capability of self-dispersing in a third solvent different from any of the first solvent and the second solvent.
• US8288425B2
  申请人：——

  公开号：US8288425B2

  公开（公告）日：2012-10-16