4-(环辛氨基)-4-氧代-丁酸 | 392714-61-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 4-(环辛氨基)-4-氧代-丁酸
• 中文别名: 4-(环辛氨基)-4-氧代丁酸；4-(环辛基氨基)-4-氧代丁酸
• 英文名称: 4-(Cyclooctylamino)-4-oxobutanoic acid
• CAS: 392714-61-3
• 化学式: C₁₂H₂₁NO₃
• mdl: MFCD01100681
• 分子量: 227.3
• InChiKey: GGGQYDFERFYSMO-UHFFFAOYSA-N

物化性质

• 沸点：
  459.4±24.0 °C(Predicted)
• 密度：
  1.09±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2924299090

文献信息

• siRNAs WITH AT LEAST TWO LIGANDS AT DIFFERENT ENDS
  申请人：SILENCE THERAPEUTICS GMBH

  公开号：US20210155926A1

  公开（公告）日：2021-05-27

  There is provided inter alia a conjugate for inhibiting expression of a target gene in a cell, said conjugate comprising a nucleic acid portion and ligand portions, said nucleic acid portion comprising at least one duplex region that comprises at least a portion of a first RNA strand and at least a portion of a second RNA strand that is at least partially complementary to the first strand, wherein said first strand is at least partially complementary to at least a portion of RNA transcribed from said target gene, said ligand portions comprising a linker moiety and a targeting ligand for in vivo targeting of cells and being conjugated exclusively to the 3′ and/or 5′ ends of one or both RNA strands, wherein the 5′ end of the first RNA strand is not conjugated, wherein: (i) the second RNA strand is conjugated at the 5′ end to the targeting ligand, and wherein (a) the second RNA strand is also conjugated at the 3′ end to the targeting ligand and the 3′ end of the first RNA strand is not conjugated; or (b) the first RNA strand is conjugated at the 3′ end to the targeting ligand and the 3′ end of the second RNA strand is not conjugated; or (c) both the second RNA strand and the first RNA strand are also conjugated at the 3′ ends to the targeting ligand; or (ii) both the second RNA strand and the first RNA strand are conjugated at the 3′ ends to the targeting ligand and the 5′ end of the second RNA strand is not conjugated.