3-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propane-1-sulfonic acid | 1034190-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]propane-1-sulfonic acid
• CAS: 1034190-23-2
• 化学式: C₁₄H₁₉N₃O₄S
• 分子量: 325.389
• InChiKey: ZIFJQJSSFWYIAO-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID
  申请人：Kong Xianqi

  公开号：US20080146642A1

  公开（公告）日：2008-06-19

  The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.

  这项发明涉及用于在受试者中（最好是人类受试者）传递3-氨基-1-丙磺酸（3APS）的方法、化合物、组合物和载体。该发明涵盖将产生或生成3APS的化合物，无论是在体外还是体内。首选的化合物包括3APS的氨基酸前药，用于预防和治疗阿尔茨海默病等用途。
• Methods, compounds, compositions and vehicles for delivering 3-amino-1-propanesulfonic acid
  申请人：BHI Limited Partnership

  公开号：EP2862581A2

  公开（公告）日：2015-04-22

  The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1 -propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.

  本发明涉及向受试者（最好是人类受试者）提供 3-氨基-1-丙磺酸（3APS）的方法、化合物、组合物和载体。本发明包括在体外或体内产生或生成 3APS 的化合物。优选的化合物包括 3APS 的氨基酸原药，其用途包括但不限于预防和治疗阿尔茨海默病。
• US8748656B2
  申请人：——

  公开号：US8748656B2

  公开（公告）日：2014-06-10
• US9499480B2
  申请人：——

  公开号：US9499480B2

  公开（公告）日：2016-11-22
• [EN] METHODS, COMPOUNDS, COMPOSITIONS AND VEHICLES FOR DELIVERING 3-AMINO-1-PROPANESULFONIC ACID<br/>[FR] PROCÉDÉS, COMPOSÉS, COMPOSITIONS ET VÉHICULES PERMETTANT DE DÉLIVRER L'ACIDE 3-AMINO-1-PROPANE SULFONIQUE
  申请人：NEURO INTERNATIONAL LTD

  公开号：WO2009019534A2

  公开（公告）日：2009-02-12

  The invention relates to methods, compounds, compositions and vehicles for delivering 3-amino-1 -propanesulfonic acid (3APS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 3APS, either in vitro or in vivo. Preferred compounds include amino acid prodrugs of 3APS for use, including but not limited to, the prevention and treatment of Alzheimer's disease.