3-(2-chloro-9-(3-methylphenyl)-9H-purin-6-yl)-phenol | 1138159-25-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-(2-chloro-9-(3-methylphenyl)-9H-purin-6-yl)-phenol
• 英文别名: 3-[2-Chloro-9-(3-methylphenyl)purin-6-yl]phenol
• CAS: 1138159-25-7
• 化学式: C₁₈H₁₃ClN₄O
• 分子量: 336.78
• InChiKey: ZNMNKAVIWBHGBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K<br/>[FR] 2 -MORPHOLINYLPURINES EN TANT QU'INHIBITEURS DE PI3K
  申请人：S BIO PTE LTD

  公开号：WO2009045174A1

  公开（公告）日：2009-04-09

  The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.

  本发明涉及作为激酶抑制剂有用的嘌呤化合物。更具体地说，本发明涉及嘌呤化合物、其制备方法、含有这些化合物的药物组合物以及在治疗增殖性疾病中使用这些化合物的用途。这些化合物可能作为药物用于治疗多种增殖性疾病，包括肿瘤和癌症以及与mTOR激酶相关的其他疾病或症状。
• 2-MORPHOLINYLPURINES AS INHIBITORS OF PI3K
  申请人：Nagaraj Harish Kumar Mysore

  公开号：US20110009403A1

  公开（公告）日：2011-01-13

  The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.

  本发明涉及嘌呤化合物，可用作激酶抑制剂。更具体地说，本发明涉及嘌呤化合物、其制备方法、含有这些化合物的药物组合物以及这些化合物在治疗增殖性疾病方面的用途。这些化合物可以作为药物治疗多种增殖性疾病，包括肿瘤和癌症以及与mTOR激酶相关或相关的其他疾病或病况。