4-(羟基氨基甲酰基)苯甲酸 | 22372-40-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(羟基氨基甲酰基)苯甲酸
• 英文名称: 4-(hydroxycarbamoyl)benzoic acid
• CAS: 22372-40-3
• 化学式: C₈H₇NO₄
• 分子量: 181.148
• InChiKey: LJRCHULXIQNSDN-UHFFFAOYSA-N

物化性质

• 密度：
  1.469±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(羟基氨基甲酰基)苯甲酸 、 丙烯醛 在 diethylaminoethyl sephacel 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.0h， 以66%的产率得到N-(4-carboxymethylphenyl)-5-hydroxyisoxazolidine
  参考文献：
  名称：

  10.24820/ark.5550190.p011.159dummy2

  摘要：

  DOI：

  10.24820/ark.5550190.p011.159dummy2
• 作为产物：
  描述：

  对醛基苯甲酸 在 polymer-bound N-hydroxybenzenesulfonamide 、 sodium methylate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 7.0h， 以95%的产率得到4-(羟基氨基甲酰基)苯甲酸
  参考文献：
  名称：

  安吉利·里米尼在固体支持物上的反应：异羟肟酸的新方法

  摘要：

  Angeli-Rimini的反应首次在固相上进行。据报道，从醛和固体负载的N-羟基苯磺酰胺开始的一种方便的一步合成异羟肟酸的方法。在用螯合剂处理粗反应混合物后，通过简单蒸发挥发性溶剂，可以高至高收率和高纯度分离出异羟肟酸酯。

  DOI：

  10.1021/jo061018g

文献信息

• Novel heteroaryl substituted piperidine derivatives which are L-CPT1 inhibitors
  申请人：Ackermann Jean

  公开号：US20070129544A1

  公开（公告）日：2007-06-07

  The invention is concerned with novel substituted piperidine derivatives of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

  这项发明涉及式(I)的新型替代哌啶衍生物，其中R1、R2、R3、R4、R5、R6、R7和X的定义如说明书和权利要求中所述，以及其生理上可接受的盐和酯。这些化合物抑制L-CPT1，可用作药物。
• Hydroxylamine derivatives as potential antimalarial agents. 1. Hydroxamic acids
  作者：John B. Hynes

  DOI：10.1021/jm00300a056

  日期：1970.11
• DNA MOTION CONTROL BASED ON NANOPORE WITH ORGANIC COATING FORMING TRANSIENT BONDING TO DNA
  申请人：Afzali-Ardakani Ali

  公开号：US20120193235A1

  公开（公告）日：2012-08-02

  A nanodevice includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an insulating layer. A nanopore is formed through the membrane, and an organic coating is provided on the insulating layer to form a transient bond to a DNA molecule in the nanopore. The transient bond is stronger than thermal motion, such that the transient bond can hold the DNA molecule against the thermal motion. When a voltage is applied across the membrane, the voltage will break the transient bond to move the DNA molecule through the nanopore in a controllable state.
• NEAR-INFRARED REFLECTIVE FILM, METHOD FOR MANUFACTURING NEAR-INFRARED REFLECTIVE FILM, AND NEAR-INFRARED REFLECTOR
  申请人：Taima Yasuo

  公开号：US20130100523A1

  公开（公告）日：2013-04-25

  The present invention provides a near-infrared reflective film and a near-infrared reflector, which can be used over large areas and are flexible, and have low haze and high visible light transmittance. The near-infrared reflective film comprises at least one unit composed of a high refractive index layer and low refractive index layer on a substrate, and is characterized in that the refractive index difference between an adjacent high refractive index layer and low refractive index layer is at least 0.1, and said high refractive index layer contains at least one type of compound (A) selected from: 1) a rutile-type titanium oxide having a volume-average particle diameter of not more than 100 nm; 2) a water-soluble polymer; and 3) the following group of compounds. Group of compounds: a carboxyl group-containing compound, hydroxamic acids, pyridine derivatives.
• METALLOENZYMES FOR BIOMOLECULAR RECOGNITION OF N-TERMINAL MODIFIED PEPTIDES
  申请人：Encodia, Inc.

  公开号：US20220283175A1

  公开（公告）日：2022-09-08

  The present disclosure relates to a metalloprotein binder that specifically binds to a N-terminally modified peptide. Also provided herein is a method and related kits for treating or analyzing a peptide using the metalloprotein binder and/or modified cleavase. In some embodiments, the method provided herein comprises binding metalloprotein binder-coding tag conjugates to a modified N-terminal amino acid residue of an immobilized peptide associated with a recording tag, transferring identifying information from the coding tag to the recording tag using a ligation or primer extension, and cleaving the modified N-terminal amino acid residue. The method and metalloprotein binders provided herein are useful for de novo peptide identification or sequencing.