γ-[N-Methyl-N-(1-methylethyl)aminomethyl]-1-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-propanol | 73596-62-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: γ-[N-Methyl-N-(1-methylethyl)aminomethyl]-1-methyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-propanol
• 英文别名: 3-(1-methyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)-4-[methyl(propan-2-yl)amino]butan-1-ol
• CAS: 73596-62-0
• 化学式: C₂₀H₃₀N₂O₂
• 分子量: 330.47
• InChiKey: RGAIGTGBIJIIJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  48.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Pyrano and thiopyrano (3,4-b) indole derivatives, processes for their preparation and pharmaceutical compositions containing them
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0005365B1

  公开（公告）日：1982-01-06
• US4179503A
  申请人：——

  公开号：US4179503A

  公开（公告）日：1979-12-18
• [EN] 1-HYDROXYALKANAMINE PYRANO(3,4-B)INDOLE DERIVATIVES
  申请人：——

  公开号：WO1979001037A1

  公开（公告）日：1979-11-29

  (EN) New compounds of formula I (FORMULA) in which R1 is lower alkyl; R2 is hydrogen or lower alkyl; R3 and R4 each independently is hydrogen, lower alkyl halo, nitro, trifluoromethyl or lower alkoxy; R5 and R6 each independently is hydrogen or lower alkyl or R5 and R6 together with the nitrogen atom form a pyrrol-1-yl, piperidino or morpholino ring; R7 is hydrogen or lower alkyl; Alk1 and Alk2 each independently is a straight or branched chain lower alkylene having one to six carbon atoms; and X is oxa or thia, and therapeutically acceptable acid addition salts thereof. The above compounds are diuretic agents, which also possess anti-hypertensive activity. They may be used alone or with other diuretic agents. Pharmaceutical compositions containing the compounds and processes for preparing the compounds are also described. (FR) Nouveaux composes de formule I (FORMULE) dans laquelle R1 est un alkyl inferieur; R2 est l"hydrogene ou un alkyle inferieur; R3 et R4 chacun independamment est un hydrogene, un alkyle inferieur, un halo, un nitro, un trifluoromethyle ou un alkoxy inferieur; R5 et R6, chacun independamment, est un hydrogene ou un alkyle inferieur ou R5 et R6 ensemble avec l"atome d"azote forment un cycle pyrrol-1-yl, piperidino ou morpholino; R7 est un hydrogene ou un alkyle inferieur; Alk1 et Alk2, chacun independamment, est une chaine alkylene inferieure lineaire ou ramifiee ayant de un a six atomes de carbone; et X est un oxa ou un thia, et leurs sels d"addition acide therapeutiquement acceptables. Les composes cites ci-dessus sont des agents diuretiques, qui ont aussi une activite anti-hypertensive Ils peuvent etre utilises seuls ou avec d"autres agents diuretiques. Des compositions pharmaceutiques contenant les composes et les procedes de preparation des composes font aussi partie de la description de l"invention.