5-(2-Pyrrolidino-ethyl)-2-methyl-1H-indole-3-carboxylic acid 1-(3,4-dichlorophenyl)-ethyl ester | 459451-07-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(2-Pyrrolidino-ethyl)-2-methyl-1H-indole-3-carboxylic acid 1-(3,4-dichlorophenyl)-ethyl ester
• 英文别名: 1-(3,4-dichlorophenyl)ethyl 2-methyl-5-(2-pyrrolidin-1-ylethyl)-1H-indole-3-carboxylate
• CAS: 459451-07-1
• 化学式: C₂₄H₂₆Cl₂N₂O₂
• 分子量: 445.389
• InChiKey: ATAKGJBBVBFNLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：US20030064991A1

  公开（公告）日：2003-04-03

  Disclosed are novel compounds having the formula 1 or a physiologically acceptable salt, amide, ester or prodrug thereof. The compounds can be used to modulate (antagonize, agonize) chemokine receptor function. Also disclosed is a method for treating a patient having an inflammatory disease and/or viral infection comprising administering an effective amount of a compound of Formula I. In particular embodiments, the invention is a method for treating a patient infected with HIV.

  揭示了具有以下结构式的新化合物 1 或其生理上可接受的盐、酰胺、酯或前药。这些化合物可用于调节（拮抗、激动）趋化因子受体功能。还揭示了一种治疗患有炎症性疾病和/或病毒感染的患者的方法，包括给予结构式I的化合物的有效量。在特定实施例中，本发明是一种治疗感染HIV的患者的方法。
• Bis (aminostyryl) naphthalene compound, synthesis intermediate thereof, and process for producion thereof
  申请人：——

  公开号：US20030069448A1

  公开（公告）日：2003-04-10

  A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. 1 (where R 2 and R 3 each denotes an unsubstituted aryl group; R 1 and R 4 each denotes an aryl group having a specific substituent such as methoxy group; and R 5 and R 6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino) benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.

  由以下通式[I]或类似通式代表的双(氨基苯乙烯基)萘化合物。 1 (其中 R 2 和 R 3 各表示一个未取代的芳基；R 1 和 R 4 各自表示具有特定取代基（如甲氧基）的芳基；以及 R 5 和 R 6 分别表示氰基或类似基团)。 一种通过例如 4-(N,N-二氨基)苯甲醛与二膦酸酯或二膦的缩合生产通式[I]代表的双(氨基苯乙烯基)萘化合物的工艺。 双（氨基苯乙烯基）萘化合物会发出强烈的黄色或红色光。该工艺可高效生产双（氨基苯乙烯基）萘化合物。
• Bis (aminostyryl) naphthalene compound, synthesis intermediate thereof, and process for production thereof
  申请人：——

  公开号：US20030073867A1

  公开（公告）日：2003-04-17

  A bis(aminostyryl)naphthalene compound represented by the general formula [I] or the like below. 1 (where R 2 and R 3 each denotes an unsubstituted aryl group; R 1 and R 4 each denotes an aryl group having a specific substituent such as methoxy group; and R 5 and R 6 each denotes a cyano group or the like.) A process for producing a bis(aminostyryl)naphthalene compound represented by the general formula [I] by condensation of, for example, 4-(N,N-diarylamino) benzaldehyde with diphosphonic ester or diphosphonium. The bis(aminostyryl)naphthalene compound emits intense yellow or red light. The process permits efficient production of the bis(aminostyryl)naphthalene compound.

  由以下通式[I]或类似通式代表的双(氨基苯乙烯基)萘化合物。 1 (其中 R 2 和 R 3 各表示一个未取代的芳基；R 1 和 R 4 各自表示具有特定取代基（如甲氧基）的芳基；以及 R 5 和 R 6 分别表示氰基或类似基团)。 一种通过例如 4-(N,N-二氨基)苯甲醛与二膦酸酯或二膦的缩合生产通式[I]代表的双(氨基苯乙烯基)萘化合物的工艺。 双（氨基苯乙烯基）萘化合物会发出强烈的黄色或红色光。该工艺可高效生产双（氨基苯乙烯基）萘化合物。
• FUNCTIONALIZED HETEROCYCLES AS MODULATORS OF CHEMOKINE RECEPTOR FUNCTION AND METHODS OF USE THEREFOR
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP1377549A1

  公开（公告）日：2004-01-07
• US6727379B2
  申请人：——

  公开号：US6727379B2

  公开（公告）日：2004-04-27