2-[1-(2-bromobenzoyl)-5-fluoroindol-3-yl]-ethyl-N,N-dimethylamine | 639805-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-[1-(2-bromobenzoyl)-5-fluoroindol-3-yl]-ethyl-N,N-dimethylamine
• 英文别名: (2-Bromophenyl)-[3-[2-(dimethylamino)ethyl]-5-fluoroindol-1-yl]methanone
• CAS: 639805-33-7
• 化学式: C₁₉H₁₈BrFN₂O
• 分子量: 389.267
• InChiKey: QMEFWFGLEABKMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Novel tetracyclic arylcarbonyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical composition containing them
  申请人：Jasti Venkateswarlu

  公开号：US20050250834A1

  公开（公告）日：2005-11-10

  The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylcarbonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy

  本发明涉及新型四环芳基羰基吲哚，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物，本文中所述的新型中间体以及含有它们的药学上可接受的组合物。本发明特别涉及一般式（I）的新型四环芳基羰基吲哚，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药学上可接受的盐，药学上可接受的溶剂化合物，本文中所述的新型中间体以及含有它们的药学上可接受的组合物。本发明还涉及制备一般式（I）的这种化合物的方法/方法，含有这种化合物的有效量/组合物的组合物，以及在治疗中使用这种化合物/组合物的用途。
• NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Suven Life Sciences Limited

  公开号：EP1517909B1

  公开（公告）日：2006-10-25
• [EN] NOVEL TETRACYCLIC ARYLCARBONYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX INDOLS D'ARYLCARBONYLE TETRACYCLIQUES PRESENTANT UNE AFFINITE POUR LE RECEPTEUR DE LA SEROTONINE UTILISES COMME AGENTS THERAPEUTIQUES, PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：SUVEN PHARMACEUTICALS LTD

  公开号：WO2004000205A2

  公开（公告）日：2003-12-31

  The present invention relates to novel tetracyclic arylcarbonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylcarbonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy