1,4-diethyl-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine | 109562-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,4-diethyl-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine
• 英文别名: 1,4-Diaethyl-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazin；1,4-Diethyl-5,7-dimethyl-6-phenylpyrrolo[3,4-d]pyridazine
• CAS: 109562-64-3
• 化学式: C₁₈H₂₁N₃
• 分子量: 279.385
• InChiKey: IJGSFOGHCQQCIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-dimethyl-1-phenyl-3,4-dipropionyl-pyrrole 在 乙醇 、 一水合肼 作用下， 生成 1,4-diethyl-5,7-dimethyl-6-phenyl-6H-pyrrolo[3,4-d]pyridazine
  参考文献：
  名称：

  Friedel-Crafts Acylations of 1-Phenyl-2,5-dimethylpyrrole and 1,2-Diphenyl-5-methylpyrrole

  摘要：

  DOI：

  10.1021/jo01086a027

文献信息

• Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds
  申请人：Anker Burke Naomi

  公开号：US20060154929A1

  公开（公告）日：2006-07-13

  6H-pyrrolo[3,4-d]pyridazine compounds and methods of their use of as ligands of voltage gated calcium channels (VGCC), useful in the treatment of neuropathic pain, and psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, panic, and bipolar disorder, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm disorders, drug addiction, drug abuse, drug withdrawal and other.

  6H-吡咯并[3,4-d]吡嗪化合物及其作为电压门控钙通道（VGCC）配体的使用方法，可用于治疗神经病性疼痛、精神和情绪障碍，例如精神分裂症、焦虑、抑郁、惊恐和双相情感障碍，以及治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律紊乱、药物成瘾、药物滥用、戒断症状等。
• Triazolo-Pyridazine Compounds and Derivatives Thereof Useful in the Treatment of Neuropathic Pain
  申请人：Lebsack D. Alec

  公开号：US20070213338A1

  公开（公告）日：2007-09-13

  The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α 2 δ-1 subunit of Ca channels.

  本发明涉及一种使用三唑并吡嗪化合物治疗神经病性疼痛的方法。本发明还涉及使用三唑并吡嗪化合物治疗精神和情绪障碍，例如精神分裂症、焦虑、抑郁、双相障碍和惊恐症，以及治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍（例如倒班引起的睡眠障碍和时差反应）、药物成瘾、药物滥用、药物戒断和其他疾病的方法。本发明还涉及新型的三唑并吡嗪化合物，它们能够选择性地结合到Ca通道的α2δ-1亚基上。
• Pyridin-4-ylamine compounds useful in the treatment of neuropathic pain
  申请人：Lim Jongwon

  公开号：US20070099950A1

  公开（公告）日：2007-05-03

  The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α 2 δ-1 subunit of Ca channels.

  本发明涉及使用三唑-吡啶嗪化合物治疗神经病性疼痛的方法。本发明还涉及使用三唑-吡啶嗪化合物治疗精神和情绪障碍，例如精神分裂症、焦虑、抑郁、双相情感障碍和惊恐症，以及治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应，药物成瘾、药物滥用、戒断症状和其他疾病。本发明还涉及新型的三唑-吡啶嗪化合物，它们选择性地结合到钙通道的α2δ-1亚单位上。
• TREATMENT OF NEUROPATHIC PAIN WITH 6H-PYRROLO(3,4-D)PYRIDAZINE COMPOUNDS
  申请人：Merck & Co., Inc.

  公开号：EP1539168A2

  公开（公告）日：2005-06-15
• US7465730B2
  申请人：——

  公开号：US7465730B2

  公开（公告）日：2008-12-16