4-(苄氧基)-4'-溴联苯 | 117692-99-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(苄氧基)-4'-溴联苯
• 英文名称: 4'-benzyloxy-4-bromobiphenyl
• 英文别名: 4-(benzyloxy)-4'-bromo-1,1'-biphenyl；1-bromo-4-(4-phenylmethoxyphenyl)benzene
• CAS: 117692-99-6
• 化学式: C₁₉H₁₅BrO
• 分子量: 339.231
• InChiKey: IOAHVBDYCWBWAR-UHFFFAOYSA-N

物化性质

• 沸点：
  453.6±33.0 °C(Predicted)
• 密度：
  1.327±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2909309090

SDS

4-苄氧基-4'-溴代二苯MSDS英文版

反应信息

• 作为反应物：
  描述：

  4-(苄氧基)-4'-溴联苯 在 盐酸 、 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 甲苯 为溶剂， 反应 10.5h， 生成 4-[tris-(4'-benzyloxy-biphenyl-4-yl)-methyl]-phenol
  参考文献：
  名称：

  自组装分子哑铃：从纳米螺旋到由客体嵌入触发的纳米胶囊。

  摘要：

  DOI：

  10.1002/anie.200600971
• 作为产物：
  描述：

  4-羟基-4'-溴联苯 、 溴甲苯 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 6.0h， 以85.8%的产率得到4-(苄氧基)-4'-溴联苯
  参考文献：
  名称：

  Polymerizable compound, polymerizable resin composition, cured polymer and liquid crystal display device

  摘要：

  这项发明的可聚合化合物由通式（I）表示：其中R为H，R′，R′O，R′COO或R′OCO，R′为具有1至约15个碳原子的直链或支链烷基或烯基基团，A1和A2分别为环己烷环或苯环，可能包括下面通式（II）表示的取代基；X为H或CH3；Y1、Y2、Y3和Y4独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，其中至少两个Y1、Y2、Y3和Y4为H，如果A1和A2均为环己烷环，则至少有一个Y1、Y2、Y3和Y4不为H：其中Y5、Y6、Y7和Y8独立地为H、F、Cl、CH3、CH3O、CF3或CF3O，至少两个Y5、Y6、Y7和Y8为H。

  公开号：

  US06388146B1

文献信息

• Synthesis of New Chiral Smectic Mesogenes with 4-(2-Phenylethyl)biphenyl and 4-[2-(3-Fluorophenyl)ethyl]biphenyl Molecular Cores
  作者：Przemysław Kula、Anna Spadło、Magdalena Żurowska、Roman Dąbrowski

  DOI：10.1055/s-0029-1219833

  日期：2010.6

  Two methods of synthesis of chosen 1-[4-(1-methyl-heptyloxycarbonyl)phenyl]-2-[4′-(2,2,3,3,4,4,4-heptafluorobutoxy­alkoxy)biphenyl-4-yl]ethanes and 1-[3-fluoro-4-(1-methylheptyloxy­carbonyl)phenyl]-2-[4′-(2,2,3,3,4,4,4-heptafluorobutoxyalkoxy)bi-phenyl-4-yl]ethanes have been proposed, checked and compared. The compounds were prepared by Sonogashira coupling of 4-benzyl­oxy-4′-ethynylbiphenyl with appropriate 4-halobenzoate esters followed by parallel hydrogenation of ethynylene bridge and debenzylation of hydroxyl group. The 1-[4-(1-methylheptyloxycarbonyl)phenyl]-2-[4′-hydroxybiphenyl-4-yl]ethane and 1-[3-fluoro-4-(methoxycarbonyl)phenyl]-2-[4′-hydroxybiphenyl-4-yl]ethane thus obtained has been transformed into final products by Mitsunobu reaction with ω-(2,2,3,3,4,4,4-heptafluorobutoxy)alkan-1-ols, followed by the replacing of an ester terminal chain in the case of second method.

  提出了两种合成选定的1-[4-(1-甲基庚氧基羰基)苯基]-2-[4′-(2,2,3,3,4,4,4-七氟丁氧基)联苯-4-基]乙烷和1-[3-氟-4-(1-甲基庚氧基羰基)苯基]-2-[4′-(2,2,3,3,4,4,4-七氟丁氧基)联苯-4-基]乙烷的方法，并进行了验证和比较。这些化合物通过Sonogashira偶联反应，将4-苄氧基-4′-乙炔基联苯与适当的4-卤代苯甲酸酯反应，随后平行进行乙炔桥的氢化和羟基的脱苄基化进行制备。得到的1-[4-(1-甲基庚氧基羰基)苯基]-2-[4′-羟基联苯-4-基]乙烷和1-[3-氟-4-(甲氧基羰基)苯基]-2-[4′-羟基联苯-4-基]乙烷通过与α-(2,2,3,3,4,4,4-七氟丁氧基)烷-1-醇的Mitsunobu反应转化为最终产品，并在第二种方法中通过替换酯末端链进行进一步处理。
• [EN] HSD17B13 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE HSD17B13 ET LEURS UTILISATIONS
  申请人：METACRINE INC

  公开号：WO2022072491A1

  公开（公告）日：2022-04-07

  Described herein are compounds that are HSD17B13 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with HSD17B13 activity.

  本文描述了一些HSD17B13抑制剂化合物，制备这些化合物的方法，包括这些化合物的药物组合物和药物，以及使用这些化合物治疗与HSD17B13活性相关的病症、疾病或障碍的方法。
• Polymerizable compound and a liquid crystal display device using the same
  申请人：Sharp Kabushiki Kaisha

  公开号：US05814378A1

  公开（公告）日：1998-09-29

  The present invention provides a polymerizable compound represented by Formula (I): ##STR1## where X represents a hydrogen atom or a methyl group; 1 represents an integer in the range of 0 to 14; m represents 0 or 1; n represents 0 or 1; p represents an integer in the range of 0 to 6; and q represents an integer in the range of 0 to 9, wherein m is 0 under the condition 1=0, and 1 under the condition 1.noteq.0.

  本发明提供了一种可聚合化合物，其由式（I）表示：##STR1## 其中，X代表氢原子或甲基基团；1代表0到14范围内的整数；m代表0或1；n代表0或1；p代表0到6范围内的整数；q代表0到9范围内的整数，其中在1=0的条件下，m为0，在1.noteq.0的条件下，m为1。
• 6,7-DIHYDROIMIDAZO [2,1-b] [1,3]OXAZINE BACTERICIDES
  申请人：Kawano Yoshikazu

  公开号：US20140031342A1

  公开（公告）日：2014-01-30

  The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R 1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R 1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R 2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.

  本发明提供了一种新型的6,7-二氢咪唑[2,1-b][1,3]噁嗪化合物，该化合物对结核杆菌、多重耐药结核杆菌和非典型酸杆菌具有优异的杀菌作用。具体而言，本发明提供了一个由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基、四氢喹啉基、四氢苯并氮杂环庚基、苯并噁唑基、苯并噻唑基、吲哚基、异吲哚啉基、萘基、喹啉基、苯基、联苯基或吡啶基，这些基团可以被替代，其中R1所表示的苯基、联苯基和吡啶基可以通过连接基直接或经过连接基与选自四氢吡啶基、二氮杂环庚基、二氮杂双环庚基、四氢三唑吡嗪基、四氢咪唑吡嗪基、氮杂双环辛基、噁唑基、哌嗪基、哌啶基、噻唑基等基团中的至少一个基团取代，其中这些基团可以被替代；而R2表示氢或低碳基。本发明还提供了一种包含上述化合物的药物组合物。
• Nematic Liquid Crystals with a Trifluoromethyl Group
  作者：Stephen M. Kelly、Graham Skelton、Cliff Jones、Vicki Minter、Rachel Tuffin

  DOI：10.1080/10587250108025060

  日期：2001.8

  We have synthesised a new class of compounds incorporating a trifluoromethyl group in the terminal alkoxy or alkenyloxy chain. Compounds containing several aromatic rings were synthesised with a view to producing compounds of high birefringence. This also included the synthesis of compounds containing a carbon-carbon triple bond. Compounds with three 1,4-disubstituted rings were synthesised in order to produce materials with a high nematic clearing point and as low a melting point as possible. Laterally fluoro-substituted compounds were prepared to generate a high positive value of the dielectric anisotropy, a low melting point and no smectic mesophases. Substances containing a cyclohexyl ring, which tend to induce a lower viscosity and compounds incorporating a bicyclo[2.2.2]octane ring were also synthesised in order to produce a high nematic clearing point and to influence the elastic constants. The (E)-trifluorobut-2-enyloxy-compounds were prepared in attempts to produce compounds with appropriate elastic constants and a high birefringence.