(R)-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-6,7-difluoro-1H-indole-2-carboxylic acid ethyl ester | 396075-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (R)-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-6,7-difluoro-1H-indole-2-carboxylic acid ethyl ester
• 英文别名: ethyl 6,7-difluoro-1-[(2R)-1-[(2-methylpropan-2-yl)oxycarbonylamino]propan-2-yl]indole-2-carboxylate
• CAS: 396075-07-3
• 化学式: C₁₉H₂₄F₂N₂O₄
• 分子量: 382.407
• InChiKey: PZWGXOOANLOZNX-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  69.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 6,7-difluoro-1H-indole-2-carboxylate 、 (5S)-5-甲基-2,2-二氧代-1,2λ⁶,3-氧代噻唑烷-3-羧酸叔丁酯 在 H+ 作用下， 生成 (R)-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-6,7-difluoro-1H-indole-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino [1,2-a] indoles

  摘要：

  本发明涉及1,2,3,4,10,10a,-六氢吡嗪并[1,2-a]吲哚衍生物以及其药学上可接受的盐、溶剂和酯，其中R1至R8具有权利要求1中所给出的意义，可用于制成药物制剂，用于治疗或预防中枢神经系统疾病、中枢神经系统损伤、心血管疾病、胃肠道疾病、尿崩症、肥胖症和睡眠呼吸暂停。

  公开号：

  US20070106076A1

文献信息

• Anti-obesity 1,2,3,4,10,10-a-hexahydropy razino [1,2-a] indoles
  申请人：——

  公开号：US20020035110A1

  公开（公告）日：2002-03-21

  The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a] indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R 1 to R 8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.

  本发明涉及1,2,3,4,10,10a,-六氢吡唑[1,2-a]吲哚衍生物以及药用可接受的盐、溶剂合物和酯，其中R1至R8具有如权利要求1中所述的意义，用于以药物制剂的形式治疗或预防中枢神经系统疾病、中枢神经系统损伤、心血管疾病、胃肠疾病、尿崩症、肥胖和睡眠呼吸暂停。
• [EN] PIPERAZINE DERIVATIVES<br/>[FR] DERIVES DE LA PIPERAZINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002010169A1

  公开（公告）日：2002-02-07

  The present invention refers to chemical compounds of formula (I) as well as pharmaceutically usable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1. They can be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnoea.

  本发明涉及化学式（I）的化合物，以及其可用于制药的盐，溶剂合物和酯，其中R1至R8具有权利要求1中给出的意义。它们可以用于制药制剂的形式，用于治疗或预防中枢神经系统的疾病，中枢神经系统的损伤，心血管疾病，胃肠疾病，尿崩症，肥胖症和睡眠呼吸暂停。
• Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a] indoles
  申请人：Bentley Mark Jonathan

  公开号：US20050239789A1

  公开（公告）日：2005-10-27

  The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R 1 to R 8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.

  本发明涉及1,2,3,4,10,10a,-六氢吡嗪并[1,2-a]吲哚衍生物，以及其药学上可接受的盐、溶剂和酯，其中R1至R8在权利要求书中所给出的意义下使用，用于制备药物制剂，用于治疗或预防中枢神经系统疾病、中枢神经系统损伤、心血管疾病、胃肠道疾病、尿崩症、肥胖症和睡眠呼吸暂停。
• Anti-obesity 1, 2, 3, 4, 10, 10a-hexahydropyrazino[1, 2-a] indoles
  申请人：——

  公开号：US20030216401A1

  公开（公告）日：2003-11-20

  The present invention is directed to 1,2,3,4,10,10a,-hexahydro-pyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R 1 to R 8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.

  本发明涉及1,2,3,4,10,10a,-六氢吡嗪[1,2-a]吲哚衍生物以及药学上可接受的盐、溶剂和酯，其中R1到R8具有权利要求1中所给定的含义，以药物制剂的形式用于治疗或预防中枢神经系统疾病、中枢神经系统损伤、心血管疾病、胃肠道疾病、尿崩症、肥胖症和睡眠呼吸暂停。
• Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles
  申请人：Bentley Jonathan Mark

  公开号：US06933387B2

  公开（公告）日：2005-08-23

  The present invention is directed to 1,2,3,4,10,10a-hexahydropyrazino [1,2-a]indole derivatives of formula (I): as well as pharmaceutically acceptable salts, hydrates and esters thereof, wherein the substituents have the meanings provided in the specification. Compounds of the present invention may be used in the treatment or prevention of obesity or Type II diabetes.

  本发明涉及公式(I)的1,2,3,4,10,10a-六氢吡嗪[1,2-a]吲哚衍生物，以及其药学上可接受的盐、水合物和酯，其中取代基的含义如规范中所提供。本发明化合物可用于治疗或预防肥胖症或2型糖尿病。