N-((Ξ)-2-bromo-propionyl)-L-alanine | 108624-37-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-((Ξ)-2-bromo-propionyl)-L-alanine
• 英文别名: N-((Ξ)-2-Brom-propionyl)-L-alanin；(2S)-2-(2-Bromopropanamido)propanoic acid；(2S)-2-(2-bromopropanoylamino)propanoic acid
• CAS: 108624-37-9
• 化学式: C₆H₁₀BrNO₃
• 分子量: 224.054
• InChiKey: ADQOGAQFIJCUCU-BKLSDQPFSA-N

物化性质

• 熔点：
  170 °C (decomp)
• 沸点：
  402.3±30.0 °C(Predicted)
• 密度：
  1.577±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  L-丙氨酸 、 2-溴丙酰溴 生成 N-((Ξ)-2-bromo-propionyl)-L-alanine
  参考文献：
  名称：

  Fodor et al., Journal of Biological Chemistry, 1950, vol. 182, p. 467,468

  摘要：

  DOI：

文献信息

• Biodegradable bio-absorbable material for clinical practice and method for producing the same
  申请人：Shirahama Hiroyuki

  公开号：US20050163822A1

  公开（公告）日：2005-07-28

  Bio-absorbable polymers such as vascular stent and suture thread for use as materials for clinical practice have almost definite dynamic properties such as tensile strength and degradation rate for absorption. When the dynamic properties thereof are elevated, therefore, the bio-absorbable polymers turn fragile, involving slower degradation rate. When the degradation rate is elevated, further, the dynamic properties are deteriorated. Disadvantageously, such bio-absorbable polymers have limited purposes for use and limited sites for use. Thus, copolymerization of bio-absorbable polymers with a cyclic depsipeptide to form a copolymer of the ring-opened and copolymerized depsipeptide can allow the adjustment of the dynamic properties and degradation rate of the resulting copolymer depending on the content of the depsipeptide.

  生物可吸收聚合物（如血管支架和缝线）作为临床实践材料，几乎具有明确的动态特性，如拉伸强度和吸收降解速率。因此，当这些动态特性提高时，生物可吸收聚合物变得脆弱，降解速率变慢。当降解速率提高时，动态特性会受到损害。不利的是，这种生物可吸收聚合物的用途和使用场所有限。因此，通过将生物可吸收聚合物与环状依赖肽共聚合，形成环开放和共聚合依赖肽的共聚物，可以根据依赖肽的含量调整所得到的共聚物的动态特性和降解速率。
• Process for the production of metal-complex carboxylic acid amides
  申请人：Schering Aktiengesellschaft

  公开号：US06045776A1

  公开（公告）日：2000-04-04

  The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex carboxylic acid and at least one solubilizing substance in dimethyl sulfoxide (DMSO) is pretreated with a dehydrating reagent, optionally with the addition of a coupling adjuvant, and is then reacted with an amine of general formula I A(NH.sub.2).sub.n (I), in which A stands for the radical of a natural or synthetic amine, and n stands for numbers 1 to 100.

  本发明涉及一种制备金属络合物羧酸酰胺的方法，其特征在于将由金属络合物羧酸和至少一种溶解剂物质组成的金属络合物羧酸混合物在二甲基亚砜（DMSO）中通过脱水试剂预处理，可选地加入偶联助剂，然后与一般式I A（NH.sub.2）.sub.n（I）中的胺反应，其中A代表天然或合成胺的基团，n代表数字1至100。
• Macrocyclic metal complex carboxylic acids, their use as well as process
  申请人：Schering Aktiengesellschaft

  公开号：US05919433A1

  公开（公告）日：1999-07-06

  The invention relates to new macrocyclic metal complex carboxylic acids of formula II ##STR1## whereby Z.sup.o stands for a metal ion equivalent of atomic numbers 58-71 and R stands for a CHX.sup.1 --CO--NH--CHY.sup.1 --(CH.sub.2).sub.f --COOH group, in which X.sup.1 and Y.sup.1, independently of one another, mean a hydrogen atom, a straight-chain or branched C.sub.1 -C.sub.7 alkyl radical, a phenyl or benzyl group and f means numbers 0 to 9. They can be used as intermediate stages for synthesis of cascade polymer complexes that are suitable as diagnostic agents.

  本发明涉及公式II的新型大环金属配合物羧酸，其中Z.sup.o代表原子序数为58-71的金属离子等效物，R代表一个CHX.sup.1--CO--NH--CHY.sup.1--(CH.sub.2).sub.f--COOH基团，其中X.sup.1和Y.sup.1独立地表示氢原子、直链或支链C.sub.1-C.sub.7烷基基团、苯基或苄基，f表示0至9的数字。它们可以用作级联聚合物配合物的中间阶段，这些配合物适用于诊断试剂。
• BIODEGRADABLE AND BIORESORBABLE MATERIAL FOR MEDICAL USE
  申请人：Goodman Co., Ltd.

  公开号：EP1832302A1

  公开（公告）日：2007-09-12

  Disclosed is a biodegradable and bioresorbable material for medical use which has excellent degradability, heat resistance and mechanical resistance. The biodegradable and bioresorbable material for medical use comprises a polymer blend of a type A polymer and a type B polymer having the following formulae, respectively: type A polymer: type B polymer: wherein each of X1 and X2 is 0 to 50 mol%; each of Y1 and Y2 is 0 to 50 mol%; each of Z1 and Z2 is 50 to 100 mol%; each of m1 and m2 is an integer of 3 to 8; R1 and R3 independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R1' and R3' independently represent an alkyl group having 1 to 2 carbon atoms; and R2, R2', R4 and R4' independently represent an alkyl group having 1 to 4 carbon atoms, provided that both of X1 and X2 should not be 0 mol%.

  本发明公开了一种生物可降解和生物可吸收医用材料，该材料具有优异的降解性、耐热性和机械耐受性。该生物可降解和生物可吸收医用材料由 A 型聚合物和 B 型聚合物的聚合物混合物组成，它们分别具有以下式子： A 型聚合物： B 型聚合物：其中 X1 和 X2 各占 0 至 50 摩尔%；Y1 和 Y2 各占 0 至 50 摩尔%；Z1 和 Z2 各占 50 至 100 摩尔%；m1 和 m2 各占 3 至 8 的整数；R1 和 R3 独立地代表氢原子或具有 1 至 4 个碳原子的烷基；R1'和 R3'独立地代表具有 1 至 2 个碳原子的烷基；以及 R2、R2'、R4 和 R4'独立地代表具有 1 至 4 个碳原子的烷基，条件是 X1 和 X2 均不得为 0 摩尔%。
• DEVICE FOR DETECTION OF HALOGENATED HYDROCARBONS
  申请人：Masarykova univerzita

  公开号：EP3173487A1

  公开（公告）日：2017-05-31

  The present invention provides a device for detection of halogenated aliphatic hydrocarbons which contains a carrier with at least one indicator of presence of halogenated aliphatic hydrocarbons, and at least one haloalkane dehalogenase (EC 3.8.1.5) immobilized on the surface of said carrier. Further provided is a method of detecting at least one halogenated aliphatic hydrocarbon in a sample or environment, wherein the sample or environment is contacted with said device which is pre-treated by hydration, and the chemical change of the indicator of presence of halogenated aliphatic hydrocarbons is evaluated.

  本发明提供了一种检测卤代脂族烃的装置，该装置包含一个载体，载体上至少有一个卤代脂族烃存在的指示剂，以及固定在所述载体表面的至少一个卤代烃脱卤酶（EC 3.8.1.5）。 进一步提供了一种检测样品或环境中至少一种卤代脂族烃的方法，其中样品或环境与经过水合预处理的所述装置接触，并评估卤代脂族烃指示剂的化学变化。