(E)-9-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-1-phenyl-non-5-en-2-ol | 873925-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-9-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-1-phenyl-non-5-en-2-ol
• CAS: 873925-40-7
• 化学式: C₂₂H₃₈O₂Si
• 分子量: 362.628
• InChiKey: NLDBXKMTZKPQFS-XDHOZWIPSA-N

物化性质

• 沸点：
  440.2±45.0 °C(Predicted)
• 密度：
  0.937±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.12
• 重原子数：
  25.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (E)-9-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-1-phenyl-non-5-en-2-ol 在 四丁基氟化铵 、 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 3-[(2S,3S)-3-(3-Methoxy-4-phenyl-butyl)-3-methyl-oxiranyl]-propan-1-ol
  参考文献：
  名称：

  Oxidatively generated electrophiles as initiators of epoxide cascade cyclization processes

  摘要：

  Oxidatively generated oxocarbenium ions are shown to be effective promoters of polyepoxide cascade cyclization reactions to form polyether compounds. The reaction conditions are neutral, ensuring that background acid-mediated processes are not operative and that other acid-sensitive functional groups, such as acetals, can be incorporated into cyclization substrates. While 5-exo pathways are more common that 6-endo pathways, a rational design has been employed to access tetrahydropyranyl ethers. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.055
• 作为产物：
  描述：

  (E)-8-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-oct-4-enoic acid ethyl ester 、 苄基氯化镁 在 二异丁基氢化铝 、 三氟化硼乙醚 、 lithium chloride 作用下， 以 二氯甲烷 、 四氢呋喃 为溶剂， 以68%的产率得到(E)-9-(tert-Butyl-dimethyl-silanyloxy)-5-methyl-1-phenyl-non-5-en-2-ol
  参考文献：
  名称：

  Oxidatively generated electrophiles as initiators of epoxide cascade cyclization processes

  摘要：

  Oxidatively generated oxocarbenium ions are shown to be effective promoters of polyepoxide cascade cyclization reactions to form polyether compounds. The reaction conditions are neutral, ensuring that background acid-mediated processes are not operative and that other acid-sensitive functional groups, such as acetals, can be incorporated into cyclization substrates. While 5-exo pathways are more common that 6-endo pathways, a rational design has been employed to access tetrahydropyranyl ethers. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2005.08.055