1-[(Dimethoxyphosphono)methylamino]cyclododecanecarboxylicacid | 1042937-16-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[(Dimethoxyphosphono)methylamino]cyclododecanecarboxylicacid
• 英文别名: 1-(dimethoxyphosphorylmethylamino)cyclododecane-1-carboxylic acid
• CAS: 1042937-16-5
• 化学式: C₁₆H₃₂NO₅P
• 分子量: 349.408
• InChiKey: SMUZDYJMKZIFLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 1-氨基环十二烷羧酸 、 亚磷酸二甲酯 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 7.0h， 以63.6%的产率得到1-[(Dimethoxyphosphono)methylamino]cyclododecanecarboxylicacid
  参考文献：
  名称：

  Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity

  摘要：

  A series of C alpha,alpha-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 mu M. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.08.010

文献信息

• Novel N-(phosphonomethyl) glycine derivatives: Design, characterization and biological activity
  作者：Emilia D. Naydenova、Petar T. Todorov、Margarita N. Topashka-Ancheva、Georgi Ts. Momekov、Tsvetelina Z. Yordanova、Spiro M. Konstantinov、Kolio D. Troev

  DOI：10.1016/j.ejmech.2007.08.010

  日期：2008.6

  A series of C alpha,alpha-disubstituted cyclic derivatives of N-(phosphonomethyl) glycine have been synthesized and characterized. They exhibited moderate clastogenicity, low antiproliferative activity on mice bone marrow cells and well expressed cytotoxicity against human tumor cell lines. The 8- and 12-membered cyclic analogs proved superior to the remaining compounds and were found to trigger apoptotic cell death in DOHH-2 cells. The latter compound caused 50% inhibition of the viability of hemobastose-derived cell lines at concentrations ranging from 20 to 67 mu M. (c) 2007 Elsevier Masson SAS. All rights reserved.