1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-3-(N-hydroxy-N-oleoylamino)-β-D-threo-pentofuranosyl>thymine | 147043-62-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-3-(N-hydroxy-N-oleoylamino)-β-D-threo-pentofuranosyl>thymine
• CAS: 147043-62-7
• 化学式: C₃₄H₆₁N₃O₆Si
• 分子量: 635.96
• InChiKey: VPNPWLVSTWXOLI-QPWMFTQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.78
• 重原子数：
  44.0
• 可旋转键数：
  20.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  113.86
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-3-(N-hydroxy-N-oleoylamino)-β-D-threo-pentofuranosyl>thymine 在 溶剂黄146 作用下， 反应 14.0h， 以70%的产率得到1-<2,3-dideoxy-3-(N-hydroxy-N-oleoylamino)-β-D-threo-pentofuranosyl>thymine
  参考文献：
  名称：

  Anti-HIV Derivatives of 1-(2,3-Dideoxy-3-N-hydroxyamino-β-D-threo-pentofuranosyl)thymine

  摘要：

  Representative examples of the title compounds including bicyclic analogs (7-9) in which a perhydro-1,3-oxazine is ortho-fused to the furanose ring, have been prepared in good to excellent yields. Compounds 5 and 7 showed marked activity against HIV-1 and HIV-2 replication in CEM cells (50% inhibitory concentration: 0.80-4.3 mu g/mL). Their di-O-acetylated (6) and mono-O-acetylated (8) derivatives were considerably less effective. To the best of our knowledge, these beta-D-threo anti-HIV nucleoside analogs constitute the first examples of anti-HIV active nucleosides bearing this configuration.

  DOI：

  10.1080/15257779408010670
• 作为产物：
  描述：

  5’-O-(叔丁基二甲基甲硅烷基)胸苷 在 重铬酸吡啶 、 盐酸羟胺 、 sodium cyanoborohydride 作用下， 以 吡啶 、 甲醇 、 二氯甲烷 、 溶剂黄146 为溶剂， 反应 3.5h， 生成 1-<5-O-(tert-butyldimethylsilyl)-2,3-dideoxy-3-(N-hydroxy-N-oleoylamino)-β-D-threo-pentofuranosyl>thymine
  参考文献：
  名称：

  Anti-HIV Derivatives of 1-(2,3-Dideoxy-3-N-hydroxyamino-β-D-threo-pentofuranosyl)thymine

  摘要：

  Representative examples of the title compounds including bicyclic analogs (7-9) in which a perhydro-1,3-oxazine is ortho-fused to the furanose ring, have been prepared in good to excellent yields. Compounds 5 and 7 showed marked activity against HIV-1 and HIV-2 replication in CEM cells (50% inhibitory concentration: 0.80-4.3 mu g/mL). Their di-O-acetylated (6) and mono-O-acetylated (8) derivatives were considerably less effective. To the best of our knowledge, these beta-D-threo anti-HIV nucleoside analogs constitute the first examples of anti-HIV active nucleosides bearing this configuration.

  DOI：

  10.1080/15257779408010670