nakijinamines F | 1395686-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: nakijinamines F
• 英文别名: Nakijinamine F；[2-(6-bromo-1H-indol-3-yl)-2-[12-(1-hydroxy-3-methylbutylidene)azaniumyl-11-oxo-2,6-diazatricyclo[7.3.1.05,13]trideca-1(12),3,5(13),7,9-pentaen-10-yl]ethyl]-trimethylazanium
• CAS: 1395686-90-4
• 化学式: C₂₉H₃₃BrN₅O₂*H
• 分子量: 564.525
• InChiKey: GHEDHSSHHYTUKL-UHFFFAOYSA-P

反应信息

• 作为反应物：
  描述：

  nakijinamines F 在 chiral HPLC 作用下， 生成 nakijinamines F 、 nakijinamines F
  参考文献：
  名称：

  Heteroaromatic alkaloids, nakijinamines, from a sponge Suberites sp.

  摘要：

  The structures of seven new secondary metabolites isolated from an Okinawan marine sponge Suberites sp., nakijinamines A (1), B (2), and F-I (3-6) and 6-bromoconicamin (7), have been elucidated on the basis of spectroscopic analysis, chemical conversion, and conformational analysis. These analyses disclosed that 1-6 were heteroaromatic alkaloids having the hybrid structures of an aaptamine-type alkaloid and an indole alkaloid, while 7 was a bromoindole alkaloid. Nakijinamine I (6) is the first example of an aaptamine-type alkaloid possessing a 1,4-dioxane ring. Antimicrobial activities of 1-7 were evaluated. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.08.018