3-[4,4-bis(2-methyl-1H-indol-3-yl)butan-2-yl]-2-methyl-1H-indole | 1207533-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[4,4-bis(2-methyl-1H-indol-3-yl)butan-2-yl]-2-methyl-1H-indole
• CAS: 1207533-44-5
• 化学式: C₃₁H₃₁N₃
• 分子量: 445.607
• InChiKey: HNPVZFKOASNQAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  47.4
• 氢给体数：
  3
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-甲基吲哚 、 丁烯-2-醛 在 silica-coated magnetic nanoparticles with a thiourea dioxide-based sulfonic acid 作用下， 以 neat (no solvent) 为溶剂， 反应 0.33h， 以94%的产率得到3-[4,4-bis(2-methyl-1H-indol-3-yl)butan-2-yl]-2-methyl-1H-indole
  参考文献：
  名称：

  具有二氧化硫脲基磺酸标签的第一个磁性纳米粒子的合成：在温和绿色条件下一锅法合成1,1,3-三（1H-吲哚-3-基）烷烃的应用

  摘要：

  描述了一种新型且可回收的具有磺酸标签{Fe3O4 @ SiO2 @（CH2）3-硫脲基二氧化硫-SO3H / HCl}的基于硫脲基二氧化钛的磁性纳米粒子。所描述的催化剂通过傅里叶变换红外光谱（FTIR），X射线...

  DOI：

  10.1039/c6ra11620e

文献信息

• Synthesis and application of modified silica sulfuric acid as a solid acid heterogeneous catalyst in Michael addition reactions
  作者：Mohammad Ali Zolfigol、Hojat Veisi、Farajollah Mohanazadeh、Alireza Sedrpoushan

  DOI：10.1002/jhet.659

  日期：2011.7

  Modified silica sulfuric acid (MSSA) as a new type of silica sulfuric acid was prepared and effectively used in the conjugate addition of indole, pyrrole, and thiols with Michael acceptors under mild conditions at room temperature. Also, MSSA was used as a catalyst for the synthesis of 1,1,3‐tri‐indolyl compounds in good to excellent yield at room temperature. J. Heterocyclic Chem., (2011).

  制备了新型的二氧化硅硫酸改性的二氧化硅硫酸（MSSA），并在室温下于温和条件下有效地用于吲哚，吡咯和硫醇与迈克尔受体的共轭加成中。此外，MSSA还用作催化剂，可在室温下以良好至极好的收率合成1,1,3-三-吲哚基化合物。J.杂环化​​学。（2011）。
• AlCl3 as a powerful catalyst for the one-pot preparation of 1,1,3-triheteroaryl compounds
  作者：Morteza Shiri、Mohammad Ali Zolfigol、Roya Ayazi-Nasrabadi

  DOI：10.1016/j.tetlet.2009.10.127

  日期：2010.1

  A general and efficient procedure for the synthesis of 1,1,3-triheteroaryl compounds in good to excellent yield at room temperature is developed. The reaction proceeds via mixed Michael and Friedel-Crafts reactions of alpha,beta-enals or alpha,beta-enones and indoles, 2-methylfuran or 2-methylthiophene in the presence of a catalytic amount of AlCl3. (C) 2009 Elsevier Ltd. All rights reserved.
• Synthesis of the first magnetic nanoparticles with a thiourea dioxide-based sulfonic acid tag: application in the one-pot synthesis of 1,1,3-tri(1H-indol-3-yl) alkanes under mild and green conditions
  作者：Mohammad Ali Zolfigol、Roya Ayazi-Nasrabadi

  DOI：10.1039/c6ra11620e

  日期：——

  A novel and recyclable thiourea dioxide-based magnetic nano particles with sulfonic acid tag Fe3O4@SiO2@(CH2)3-thiourea dioxide-SO3H/HCl} was described. The described catalyst was fully characterized by Fourier transform infrared spectroscopy (FTIR), X-ray...

  描述了一种新型且可回收的具有磺酸标签Fe3O4 @ SiO2 @（CH2）3-硫脲基二氧化硫-SO3H / HCl}的基于硫脲基二氧化钛的磁性纳米粒子。所描述的催化剂通过傅里叶变换红外光谱（FTIR），X射线...