2-lithiopyrimidine | 155191-75-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-lithiopyrimidine
• CAS: 155191-75-6
• 化学式: C₄H₃LiN₂
• 分子量: 86.0222
• InChiKey: HSEHEOWSDZJFIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.73
• 重原子数：
  7.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.78
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  肉桂醛 、 2-lithiopyrimidine 以 四氢呋喃 为溶剂， 以53%的产率得到1-β-styryl-1-(2-pyrimidinyl)methanol
  参考文献：
  名称：

  Stannylation in the electrophilic 2- and 4/6-pyrimidine position and the use of Stannylpyrimidines in coupling and Tin-lithium exchange reactions.

  摘要：

  2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.

  DOI：

  10.1016/s0040-4020(01)80750-x
• 作为产物：
  描述：

  2-(三丁基锡)嘧啶 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 生成 2-lithiopyrimidine
  参考文献：
  名称：

  Stannylation in the electrophilic 2- and 4/6-pyrimidine position and the use of Stannylpyrimidines in coupling and Tin-lithium exchange reactions.

  摘要：

  2-Stannylpyrimidines have been prepared by stannyl anion substitution in 2-chloropyrimidines. Stannylation in the 4-position was via the iodo-derivative or via the 4-lithio derivative and lithium-tin transmetallation. Tin-lithium exchange in the 2-position resulted in 2-lithiopyrimidine. Ketones were formed from the stannylpyrimidines and acid chlorides, aryl bromides required Pd-catalysis for coupling reaction.

  DOI：

  10.1016/s0040-4020(01)80750-x