3-p-Carboxyphenyl-5-propyl-1,2,4-oxadiazol | 10185-91-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-p-Carboxyphenyl-5-propyl-1,2,4-oxadiazol
• 英文别名: 4-(5-propyl-[1,2,4]oxadiazol-3-yl)-benzoic acid；4-(5-Propyl-1,2,4-oxadiazol-3-yl)benzoic acid
• CAS: 10185-91-8
• 化学式: C₁₂H₁₂N₂O₃
• 分子量: 232.239
• InChiKey: OQGABBIKGHYGKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE
  申请人：PTC Therapeutics, Inc.

  公开号：US20170204073A1

  公开（公告）日：2017-07-20

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.