2-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]-1-morpholino-ethanone | 1224704-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]-1-morpholino-ethanone
• 英文别名: 2-(4-(5-Chloro-4-(imidazo[1,2-a]pyridin-3-yl)pyrimidin-2-ylamino)-3-methoxyphenyl)-1-morpholinoethanone；2-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-ylpyrimidin-2-yl)amino]-3-methoxyphenyl]-1-morpholin-4-ylethanone
• CAS: 1224704-23-7
• 化学式: C₂₄H₂₃ClN₆O₃
• 分子量: 478.938
• InChiKey: SNUYAPYTXROTFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.9
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-(2-butoxyvinyl)-2,5-dichloropyrimidine 在 N-溴代丁二酰亚胺(NBS) 、 对甲苯磺酸 作用下， 以 1,4-二氧六环 、 2-戊醇 、 水 为溶剂， 生成 2-[4-[(5-chloro-4-imidazo[1,2-a]pyridin-3-yl-pyrimidin-2-yl)amino]-3-methoxy-phenyl]-1-morpholino-ethanone
  参考文献：
  名称：

  Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

  摘要：

  Following the discovery of imidazopyridine 1 as a potent IGF-1R tyrosine kinase inhibitor, the aniline part has been modified with the aim to optimize the properties of this series. The structure-activity relationships against IGF-1R kinase activity as well as inhibition of the hERG ion channel are discussed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.090

文献信息

• NOVEL COMPOUNDS 515
  申请人：Ducray Richard

  公开号：US20100105655A1

  公开（公告）日：2010-04-29

  There is provided novel pyrimidine derivatives of formula (I) or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  提供了化学式（I）的新型嘧啶衍生物或其药用盐，以及它们的制备方法、含有它们的药物组合物以及它们在治疗中的应用。
• Lipids
  申请人：Eaton Anthony William Michael

  公开号：US20060148761A1

  公开（公告）日：2006-07-06

  Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

  描述了一种能够与多聚阴离子形成复合物的双极脂质。该脂质由阳离子头部连接到疏水骨架和亲水尾部组成，能够自组装形成在水溶液中稳定的复合物。这种脂质特别适用于将生物活性物质如核酸传递到体外和体内的细胞中。
• LIPIDS
  申请人：CELLTECH THERAPEUTICS LIMITED

  公开号：EP1070047A2

  公开（公告）日：2001-01-24
• BIPOLAR LIPIDS AND THEIR USE FOR THE DELIVERY OF BIOACTIVE SUBSTANCES
  申请人：Celltech R&D Limited

  公开号：EP1187807A1

  公开（公告）日：2002-03-20
• TARGETED LIPID PARTICLES
  申请人：Celltech R&D Limited

  公开号：EP1204428A2

  公开（公告）日：2002-05-15