N²-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N⁴-(2-methyl-2H-indazol-6-yl)pyrimidine-2,4-diamine | 1584164-76-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N²-[2-(5-methoxy-1H-indol-3-yl)ethyl]-N⁴-(2-methyl-2H-indazol-6-yl)pyrimidine-2,4-diamine
• 英文别名: 2-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-4-N-(2-methylindazol-6-yl)pyrimidine-2,4-diamine
• CAS: 1584164-76-0
• 化学式: C₂₃H₂₃N₇O
• 分子量: 413.482
• InChiKey: CGTPTNXKVUCEJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  92.7
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 4-INDAZOLYLAMINO-2-(2-(INDOL-3-YL)ETHYL)AMINOPYRIMIDINES USEFUL FOR THE TREATMENT OF CANCER
  申请人：NOVIGA RESEARCH AB

  公开号：US20150225374A1

  公开（公告）日：2015-08-13

  The invention provides novel indazole-substituted diaminopyrimidines of formula I, to methods of preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods for using such compounds in treatment of diseases including cancer; wherein R 1 -R 8 are as defined in the specification.