1-N-(t-Butoxycarbonyl)amino-4-methylsulfonyloxy-2,Z-butene | 159498-82-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-N-(t-Butoxycarbonyl)amino-4-methylsulfonyloxy-2,Z-butene
• 英文别名: [(Z)-4-[(2-methylpropan-2-yl)oxycarbonylamino]but-2-enyl] methanesulfonate
• CAS: 159498-82-5
• 化学式: C₁₀H₁₉NO₅S
• 分子量: 265.331
• InChiKey: HELGSNLMHICANP-WAYWQWQTSA-N

物化性质

• 沸点：
  430.2±45.0 °C(Predicted)
• 密度：
  1.169±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-N-(t-Butoxycarbonyl)amino-4-methylsulfonyloxy-2,Z-butene 在 氢氧化钾 、 sodium hydride 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 Carbamic acid, [4-[[5-(1-piperidinylcarbonyl)-3-thienyl]oxy]-2-butenyl]-,1,1-dimethylethyl ester, (Z)-
  参考文献：
  名称：

  Synthesis of a piperidinomethylthiophene derivative as H2-antagonist with inhibitory activity against Helicobacter pylori

  摘要：

  Piperidinomethylthiophene derivatives 12 were synthesized, which showed a potent H-2 antagonistic activity together with a moderate inhibitory activity against Helicobacter pylori. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00313-7
• 作为产物：
  描述：

  二碳酸二叔丁酯 在 三乙胺 作用下， 生成 1-N-(t-Butoxycarbonyl)amino-4-methylsulfonyloxy-2,Z-butene
  参考文献：
  名称：

  Synthesis of a piperidinomethylthiophene derivative as H2-antagonist with inhibitory activity against Helicobacter pylori

  摘要：

  Piperidinomethylthiophene derivatives 12 were synthesized, which showed a potent H-2 antagonistic activity together with a moderate inhibitory activity against Helicobacter pylori. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00313-7

文献信息

• Guanidino compounds as regulators of nitric oxide synthase
  申请人：Abbott Laboratories

  公开号：US05380945A1

  公开（公告）日：1995-01-10

  Compounds of the formula: ##STR1## useful as regulators of nitric oxide synthase that indirectly modulate cyclic guanosine monophosphate (cGMP), pharmaceutical compositions thereof, for treating disorders of vascular smooth muscles, macrophages, neurons, platelets, bronchial smooth muscles, optic muscles and gastrointestinal smooth muscles, sickle cell anemia and diabetes.

  式为：##STR1## 的化合物，可用作一氧化氮合酶的调节剂，间接调节环鸟苷酸单磷酸（cGMP），其药物组合物用于治疗血管平滑肌，巨噬细胞，神经元，血小板，支气管平滑肌，视肌和胃肠平滑肌的疾病，镰状细胞贫血和糖尿病。
• US5380945A
  申请人：——

  公开号：US5380945A

  公开（公告）日：1995-01-10
• Synthesis of a piperidinomethylthiophene derivative as H2-antagonist with inhibitory activity against Helicobacter pylori
  作者：Koichi Kojima、Katsuyoshi Nakajima、Hitoshi Kurata、Keiichi Tabata、Yukio Utsui

  DOI：10.1016/0960-894x(96)00313-7

  日期：1996.8

  Piperidinomethylthiophene derivatives 12 were synthesized, which showed a potent H-2 antagonistic activity together with a moderate inhibitory activity against Helicobacter pylori. Copyright (C) 1996 Elsevier Science Ltd