(2S,3R,4S)-4-amino-2-(hydroxymethyl)oxolan-3-ol | 189133-21-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (2S,3R,4S)-4-amino-2-(hydroxymethyl)oxolan-3-ol
• CAS: 189133-21-9
• 化学式: C₅H₁₁NO₃
• 分子量: 133.147
• InChiKey: WLEBAMQGPQIQTE-VAYJURFESA-N

物化性质

• 沸点：
  320.7±42.0 °C(Predicted)
• 密度：
  1.294±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  75.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,3R,4S)-4-amino-2-(hydroxymethyl)oxolan-3-ol 在 盐酸 、 三乙胺 作用下， 以 乙二醇乙醚 为溶剂， 反应 21.0h， 生成 2-amino-7-[(3S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  Synthesis of some pyrrolo[2,3-d]pyrimidine and 1,2,3-triazole isonucleosides

  摘要：

  Nucleoside analogues 8, 9, 10 and 11, in which a pyrrolo[23-d]pyrimidine ring is linked to a 2-hydroxymethyl-3-hydroxytetrahydrofuran, have been prepared. The azide 16 used as an intermediate in the routes to these compounds also gave access to the 1, 2, 3-triazole isonucleosides 12 and 13. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00102-6
• 作为产物：
  描述：

  在 platinum(IV) oxide 盐酸 、 sodium tetrahydroborate 、 sodium azide 、 ammonium chloride 、 氢气 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 甲醇 、 乙醇 、 水 为溶剂， 25.0 ℃ 、101.33 kPa 条件下， 反应 52.0h， 生成 (2S,3R,4S)-4-amino-2-(hydroxymethyl)oxolan-3-ol
  参考文献：
  名称：

  Synthesis of some pyrrolo[2,3-d]pyrimidine and 1,2,3-triazole isonucleosides

  摘要：

  Nucleoside analogues 8, 9, 10 and 11, in which a pyrrolo[23-d]pyrimidine ring is linked to a 2-hydroxymethyl-3-hydroxytetrahydrofuran, have been prepared. The azide 16 used as an intermediate in the routes to these compounds also gave access to the 1, 2, 3-triazole isonucleosides 12 and 13. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00102-6

文献信息

• Synthesis of some pyrrolo[2,3-d]pyrimidine and 1,2,3-triazole isonucleosides
  作者：Ratnakar R. Talekar、Richard H. Wightman

  DOI：10.1016/s0040-4020(97)00102-6

  日期：1997.3

  Nucleoside analogues 8, 9, 10 and 11, in which a pyrrolo[23-d]pyrimidine ring is linked to a 2-hydroxymethyl-3-hydroxytetrahydrofuran, have been prepared. The azide 16 used as an intermediate in the routes to these compounds also gave access to the 1, 2, 3-triazole isonucleosides 12 and 13. (C) 1997 Elsevier Science Ltd.