2-methyl-4H-thieno[3,2-b]pyrrole | 956296-71-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡咯类
• 英文名称: 2-methyl-4H-thieno[3,2-b]pyrrole
• 英文别名: Methylthienopyrrolin
• CAS: 956296-71-2
• 化学式: C₇H₇NS
• mdl: MFCD19227395
• 分子量: 137.205
• InChiKey: VRTIWSBKSLWMKI-UHFFFAOYSA-N

物化性质

• 沸点：
  264.0±20.0 °C(Predicted)
• 密度：
  1.274±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  44
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-4H-thieno[3,2-b]pyrrole 在 iron(III) chloride 、 potassium carbonate 作用下， 以 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 180.0h， 生成 4-(2,4-dimethyl-4H-thieno[3,2-b]pyrrol-6-yl)-N-(4-fluoro-2-methoxy-5-nitrophenyl)pyrimidin-2-amine
  参考文献：
  名称：

  2-ARYLAMINO PYRIDINE, PYRIDINE OR TRIAZINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF

  摘要：

  公开号：

  EP3345906B1
• 作为产物：
  描述：

  2-Methyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid 在 sodium hydroxide 、 乙二醇 作用下， 反应 4.0h， 以70.1%的产率得到2-methyl-4H-thieno[3,2-b]pyrrole
  参考文献：
  名称：

  FLUORESCENT COMPOUND AND LABELING AGENT COMPRISING THE SAME

  摘要：

  公开号：

  EP2022794B1

文献信息

• [EN] INDACENO DERIVATIVES AS ORGANIC SEMICONDUCTORS<br/>[FR] DÉRIVÉS D'INDACÉNO EN TANT QUE SEMI-CONDUCTEURS ORGANIQUES
  申请人：BASF SE

  公开号：WO2020078815A1

  公开（公告）日：2020-04-23

  The present invention provides compounds comprising at least one unit of formula (1) or (1') as well as a process for the preparation of the compounds, intermediates of this process, electronic devices comprising the compounds, and the use of the compounds as semiconducting materials.

  本发明提供了包含至少一个式（1）或（1'）单元的化合物，以及用于制备这些化合物的过程，该过程的中间体，包含这些化合物的电子器件，以及将这些化合物用作半导体材料的用途。
• [EN] NAPHTHOINDACENODITHIOPHENES AND POLYMERS<br/>[FR] NAPHTOINDACÉNODITHIOPHÈNES ET POLYMÈRES
  申请人：BASF SE

  公开号：WO2017097924A1

  公开（公告）日：2017-06-15

  Polymers comprising at least one unit of formula1 and compounds of the formula 1' wherein, in formulae 1 and 1' n is 0, 1, 2, 3 or 4 mis 0, 1, 2, 3 or 4 X is at each occurrence selected from the group consisting of O, S, Se or Te, Q is at each occurrence selected from the group consisting of C, Si or Ge R is at each occurrence selected from the group consisting of hydrogen, C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-12-cycloalkyl, C6-18-aryl, R2, R2', R* are at each occurrence independently selected from the group consisting of hydrogen, C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl,C5-12-cycloalkyl, C6-18-aryl, 5 to 20 membered hetero-aryl, OR21, OC(O)-R21, C(O)-OR21, C(O)-R21, NR21R22, NR21-C(O)R22, C(O)-NR21R22, N[C(O)R21][C(O)R22], SR21, halogen, CN, SiRSisRSitRSiu and OH, L1 and L2 are independently from each other and at each occurrence selected from the group consisting of C6-30-arylene, 5 to 30 membered heteroarylene.

  聚合物包括至少一个式1的单元和式1'的化合物，其中，在式1和1'中，n为0、1、2、3或4，X在每次出现时从O、S、Se或Te中选择，Q在每次出现时从C、Si或Ge中选择，R在每次出现时从氢、C1-30-烷基、C2-30-烯基、C2-30-炔基、C5-12-环烷基、C6-18-芳基中选择，R2、R2'、R*在每次出现时独立地从氢、C1-30-烷基、C2-30-烯基、C2-30-炔基、C5-12-环烷基、C6-18-芳基、5至20个成员的杂芳基、OR21、OC(O)-R21、C(O)-OR21、C(O)-R21、NR21R22、NR21-C(O)R22、C(O)-NR21R22、N[C(O)R21][C(O)R22]、SR21、卤素、CN、SiRSisRSitRSiu和OH中选择，L1和L2相互独立且在每次出现时从C6-30-芳基、5至30个成员的杂芳基中选择。
• Ether-based polymers as photo-crosslinkable dielectrics
  申请人：BASF SE

  公开号：US10020456B2

  公开（公告）日：2018-07-10

  Polymers comprising at least one unit of formula (1) wherein n is 0 or 1, m and p are independently from each other 0, 1, 2, 3, 4, 5 or 6, provided that the sum of n, m and p is at least 2, and n and p are not 0 at the same time, Ar1 and Ar2 are independently from each other C6-14-arylene or C6-14-aryl, which may be substituted with 1 to 4 substituents independently selected from the group consisting of C1-30-alkyl, C2-30-alkenyl, C2-30-alkynyl, C5-8-cycloalkyl, C6-14-aryl and 5 to 14 membered heteroaryl, and X1, X2 and X3 are independently from each other and at each occurrence O or S, compositions comprising these polymers, and electronic devices comprising a layer formed from the compositions. Preferably, the electronic device is an organic field effect transistor and the layer is the dielectric layer.

  至少包含一个式 (1) 单元的聚合物 其中 n 为 0 或 1，m 和 p 互不独立地为 0、1、2、3、4、5 或 6，条件是 n、m 和 p 之和至少为 2，且 n 和 p 不同时为 0，Ar1 和 Ar2 互不独立地为 C6-14- 芳基或 C6-14- 芳基、C1-30-烷基、C2-30-烯基、C2-30-炔基、C5-8-环烷基、C6-14-芳基和 5-14 位杂芳基组成的组中，可被 1 至 4 个取代基取代；X1、X2 和 X3 相互独立，且每次出现时均为 O 或 S。电子器件最好是有机场效应晶体管，层最好是介电层。
• 2-arylamino pyridine, pyrimidine or triazine derivatives, preparation method and use thereof
  申请人：Wuxi Shuangliang Biotechnology Co., Ltd.

  公开号：US10377747B2

  公开（公告）日：2019-08-13

  The present disclosure relates to 2-arylamino pyridine, pyrimidine, or triazine derivatives, and the preparation method and use thereof. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may act on certain mutated forms of epidermal growth factor receptor, for example the L858R activating mutant, the delE746_A750 mutant, the Exonl9 deletion activating mutant, and the T790M resistance mutant, so as to be used for treatment and prevention of diseases and medical conditions. The 2-arylamino pyridine, pyrimidine, or triazine derivatives may be used for treatment and prevention of cancer. The present disclosure also relates to a pharmaceutical composition comprising 2-arylamino pyridine, pyrimidine, or triazine derivatives, intermediates useful in the manufacture of 2-arylamino pyridine, pyrimidine, or triazine derivatives, and to methods of treatment of diseases mediated by various different forms of EGFR using 2-arylamino pyridine, pyrimidine, or triazine derivatives.

  本公开涉及 2-芳基氨基吡啶、嘧啶或三嗪衍生物及其制备方法和用途。2-芳基氨基吡啶、嘧啶或三嗪衍生物可作用于表皮生长因子受体的某些突变形式，例如 L858R 激活突变体、delE746_A750 突变体、Exonl9 缺失激活突变体和 T790M 抗性突变体，从而可用于治疗和预防疾病和病症。2-芳基氨基吡啶、嘧啶或三嗪衍生物可用于治疗和预防癌症。本公开还涉及包含 2-芳基氨基吡啶、嘧啶或三嗪衍生物的药物组合物，用于制造 2-芳基氨基吡啶、嘧啶或三嗪衍生物的中间体，以及使用 2-芳基氨基吡啶、嘧啶或三嗪衍生物治疗由各种不同形式的表皮生长因子受体介导的疾病的方法。
• Semiconducting polymer
  申请人：BASF SE

  公开号：US10815236B2

  公开（公告）日：2020-10-27

  Compounds of formula (I) and polymers comprising at least a structure of formula (II), wherein T1 or T2 are independently of each other a group of Formula (III), Formula (iv) Qa, Qb, Qc, Qd, Qe or Qf are independently of each other O, S or NR1.

  式(I)化合物和至少包含式(II)结构的聚合物，其中 T1 或 T2 独立地互为式(III)基团，式(iv) Qa、Qb、Qc、Qd、Qe 或 Qf 独立地互为 O、S 或 NR1。