2-Aminohex-5-ynamide | 763075-22-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Aminohex-5-ynamide
• CAS: 763075-22-5
• 化学式: C₆H₁₀N₂O
• 分子量: 126.158
• InChiKey: WIJLSVPWVARZEW-UHFFFAOYSA-N

物化性质

• 沸点：
  287.4±35.0 °C(Predicted)
• 密度：
  1.085±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Aminohex-5-ynamide 在 盐酸 、 aminopeptidase from Pseudomonas putida 作用下， 生成 D,L-2-amino-5-hexynoic acid
  参考文献：
  名称：

  Pd-Catalyzed cyclization reactions of acetylene-containing α-amino acids

  摘要：

  Acetylene-containing amino acids, obtained in enantiopure form via an enzymatic resolution process, serve as versatile intermediates in the synthesis of various highly functionalized heterocycles. The key transformations, intramolecular OC- and NC-bond formation, proceed via Pd-catalysis. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00910-1
• 作为产物：
  描述：

  2-Amino-5-hexynenitrile 在 水 作用下， 生成 2-Aminohex-5-ynamide
  参考文献：
  名称：

  Pd-Catalyzed cyclization reactions of acetylene-containing α-amino acids

  摘要：

  Acetylene-containing amino acids, obtained in enantiopure form via an enzymatic resolution process, serve as versatile intermediates in the synthesis of various highly functionalized heterocycles. The key transformations, intramolecular OC- and NC-bond formation, proceed via Pd-catalysis. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00910-1

文献信息

• Pd-Catalyzed cyclization reactions of acetylene-containing α-amino acids
  作者：Larissa B. Wolf、Kim C.M.F. Tjen、Floris P.J.T. Rutjes、Henk Hiemstra、Hans E. Schoemaker

  DOI：10.1016/s0040-4039(98)00910-1

  日期：1998.7

  Acetylene-containing amino acids, obtained in enantiopure form via an enzymatic resolution process, serve as versatile intermediates in the synthesis of various highly functionalized heterocycles. The key transformations, intramolecular OC- and NC-bond formation, proceed via Pd-catalysis. (C) 1998 Elsevier Science Ltd. All rights reserved.