3,3-二甲基八氢喹噁啉-2(1H)-酮 | 99976-77-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3,3-二甲基八氢喹噁啉-2(1H)-酮
• 中文别名: 3,3-二甲基-1,4,4A,5,6,7,8,8A-八氢喹喔啉-2-酮
• 英文名称: cis-3,3-dimethyl-decahydroquinoxalin-2-one
• 英文别名: 3,3-dimethyl-decahydroquinoxalin-2-one；3,3-dimethyloctahydroquinoxalin-2(1H)-one；3,3-dimethyl-1,4,4a,5,6,7,8,8a-octahydroquinoxalin-2-one
• CAS: 99976-77-9
• 化学式: C₁₀H₁₈N₂O
• mdl: MFCD09731949
• 分子量: 182.266
• InChiKey: WCIJYVHCHODWEJ-UHFFFAOYSA-N

物化性质

• 熔点：
  165-166 °C
• 沸点：
  341.6±35.0 °C(Predicted)
• 密度：
  0.983±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.95
• 重原子数：
  13.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  41.13
• 氢给体数：
  2.0
• 氢受体数：
  2.0

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  1,2-二氨基环己烷 、 丙酮氰醇 生成 3,3-二甲基八氢喹噁啉-2(1H)-酮
  参考文献：
  名称：

  LAI, JOHN T.

  摘要：

  DOI：

文献信息

• [EN] DECAHYDROQUINOXALINE DERIVATIVES AND ANALOGS THEREOF<br/>[FR] DÉRIVÉS DE DÉCAHYDROQUINOXALINE ET LEURS ANALOGUES
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2013137479A1

  公开（公告）日：2013-09-19

  A heterocyclic compound represented by the general formula (1) or a salt thereof: wherein m, l, and n respectively represent an integer of 1 or 2; X represents -O- or -CH2-; R1 represents hydrogen, a lower alkyl group, a hydroxy-lower alkyl group, a protecting group, or a tri-lower alkylsilyloxy-lower alkyl group; R2 and R3, which are the same or different, each independently represent hydrogen or a lower alkyl group; or R2 and R3 are bonded to form a cyclo-C3-C8 alkyl group; and R4 represents an aromatic group or a heterocyclic group, wherein the aromatic or heterocyclic group may have one or more arbitrary substituent(s).

  通用式（1）表示的杂环化合物或其盐：其中m，l和n分别表示1或2的整数；X表示-O-或-CH2-；R1表示氢，较低的烷基基团，羟基较低的烷基基团，保护基或三较低烷氧基较低的烷基基团；R2和R3，相同或不同，各自独立地表示氢或较低的烷基基团；或R2和R3结合形成环-C3-C8烷基基团；R4表示芳香基团或杂环基团，其中芳香基团或杂环基团可能具有一个或多个任意取代基。
• Substituted 2-keto-1,4-diazacycloalkanes and UV-light-stabilized
  申请人：The B. F. Goodrich Company

  公开号：US04190571A1

  公开（公告）日：1980-02-26

  Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-carbon bridge between the N.sup.1 and N.sup.4 atoms of the diaza ring, the remaining portion of the ring having a variable length bridge of two or more carbon atoms, (b) an N-adjacent carbonyl in the fixed two-carbon bridge, and (c) at least one N.sup.4 -adjacent carbon atom of the diaza ring is polysubstituted, that is, has two substituents which may be cyclizable. Compositions containing (a) the polysubstituted 2-keto-1,4-diazacycloalkanes of this invention, and (b) prior art polysubstituted 2-keto-1,4-diazacycloalkanes, exhibit excellent stability to UV light.

  新型多取代2-酮基-1,4-二氮杂环烷是对于受紫外光（UV）降解影响的材料具有强大稳定性的稳定剂，特别是对于聚烯烃。本发明的环状2-酮化合物具有（a）在二氮杂环烷的N.sup.1和N.sup.4原子之间有一个固定的两个碳桥，环的其余部分具有两个或更多碳原子的可变长度桥，（b）在固定的两个碳桥中有一个N-相邻的酮基，以及（c）至少有一个二氮杂环烷的N.sup.4-相邻碳原子是多取代的，即具有两个可能被环化的取代基。包含（a）本发明的多取代2-酮基-1,4-二氮杂环烷和（b）先前的多取代2-酮基-1,4-二氮杂环烷的组合物，对于UV光具有优异的稳定性。
• Substituted 2-keto-1,4-diazacycloalkanes
  申请人：The B. F. Goodrich Company

  公开号：US04466916A1

  公开（公告）日：1984-08-21

  Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-carbon bridge between the N.sup.1 and N.sup.4 atoms of the diaza ring, the remaining portion of the ring having a variable length bridge of two or more carbon atoms, (b) and N-adjacent carbonyl in the fixed two-carbon bridge, and (c) at least one N.sup.4 -adjacent carbon atom of the diaza ring is polysubstituted, that is, has two substituents which may be cyclizable. Compositions containing (a) the polysubstituted 2-keto-1,4-diazacycloalkanes of this invention, and (b) prior art polysubstituted 2-keto-1,4-diazacycloalkanes, exhibit excellent stability to UV light.

  新型多取代2-酮-1,4-二氮杂环烷是对于受紫外（UV）光降解的材料具有强大的稳定剂，特别是对于聚烯烃。本发明的环状2-酮化合物具有：（a）在二氮杂环烷的N.sup.1和N.sup.4原子之间有一个固定的两碳桥，环的其余部分具有两个或更多碳原子的可变长度桥，（b）固定的两碳桥中有一个N-邻接的羰基，以及（c）至少有一个二氮杂环烷的N.sup.4-邻接碳原子是多取代的，即具有可以环化的两个取代基。含有（a）本发明的多取代2-酮-1,4-二氮杂环烷，以及（b）先前的多取代2-酮-1,4-二氮杂环烷的组合物，表现出对UV光的优异稳定性。
• 2-Keto-1,4-diazacycloalkanes
  申请人：The B. F. Goodrich Company

  公开号：US04292240A1

  公开（公告）日：1981-09-29

  Novel polysubstituted 2-keto-1,4-diazacycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic 2-keto compounds of this invention have (a) a fixed two-carbon bridge between the N.sup.1 and N.sup.4 atoms of the diaza ring, the remaining portion of the ring having a variable length bridge of two or more carbon atoms, (b) an N-adjacent carbonyl in the fixed two-carbon bridge, and (c) at least one N.sup.4 -adjacent carbon atom of the diaza ring is polysubstituted, that is, has two substituents which may be cyclizable. Compositions containing (a) the polysubstituted 2-keto-1,4-diazacycloalkanes of this invention, and (b) prior art polysubstituted 2-keto-1,4-diazacycloalkanes, exhibit excellent stability to UV light.

  新型多取代的2-酮基-1,4-二氮杂环烷是材料在紫外线（UV）光降解下的强力稳定剂，特别适用于聚烯烃。本发明的环状2-酮化合物具有(a)在二氮杂环烷的N.sup.1和N.sup.4原子之间有一个固定的二碳桥，环的其余部分具有两个或更多碳原子的可变长度桥，(b) 固定的二碳桥中有一个N-邻近的羰基，以及(c) 至少一个二氮杂环烷的N.sup.4-邻近碳原子是多取代的，即具有两个可以环化的取代基。包含(a)本发明的多取代2-酮基-1,4-二氮杂环烷和(b)现有技术的多取代2-酮基-1,4-二氮杂环烷的组合物，对UV光具有良好的稳定性。
• UV-light-stabilized compositions containing substituted 1,5-diazacycloalkanes and 2-keto-1,5-diazacycloalkanes, novel compounds and synthesis thereof
  申请人：The B.F. GOODRICH Company

  公开号：EP0001560A2

  公开（公告）日：1979-05-02

  Novel polysubstituted 1,5-diazacycloalkanes and polysubstituted 2-keto-1,5- diazcycloalkanes are powerful stabilizers for materials subject to ultraviolet (UV) light degradation, particularly for polyolefins. The cyclic compounds of this invention have (a) a fixed three-carbon bridge between the N' and N5 atoms of the diaza ring, the remaining portion of the ring having a variable length bridge of two or more carbon stoms, (b) an N-adjacent carbon atom of the diaza ring is polysubstituted, that is, has two substituents which may be cyclizable. Compositions containing (a) the polysubstituted 1,5-diazacycloalkanes and polysubstituted 2-keto-1,5- diazacycloalkanes of this invention, and (b) prior art polysubstituted 1,5-diazacycloalkanes and polysubstituted 2-keto-1,5-diazscycloalkanes, exhibit excellent stability to UV light. A novel synthesis for preparing polysubstituted 2- keto-1,5- diazacycloalkanes is disclosed.

  新颖的多取代 1,5-二氮环烷和多取代 2-酮基-1,5-二氮环烷是紫外线（UV）降解材料的强力稳定剂，尤其适用于聚烯烃。本发明的环状化合物(a)在重氮环的 N'和 N5 原子间有一个固定的三碳桥，环的其余部分有一个由两个或多个碳原子组成的长度可变的桥，(b)重氮环的一个 N 相邻碳原子是多取代的，即有两个可环化的取代基。 含有 (a) 本发明的多取代 1,5-二氮杂环烷烃和多取代 2-酮基-1,5-二氮杂环烷烃，以及 (b) 现有技术中的多取代 1,5-二氮杂环烷烃和多取代 2-酮基-1,5-二氮杂环烷烃的组合物，对紫外线具有极佳的稳定性。 本发明公开了一种制备多取代 2-酮基-1,5-重氮环烷的新型合成方法。