4-(2,3-Dimethylphenyl)aniline | 1221971-57-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,3-Dimethylphenyl)aniline
• CAS: 1221971-57-8
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: XZLVMDKLUSLUSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2,3-Dimethylphenyl)aniline 在 氢气 作用下， 以 乙醇 、 水 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 28.0h， 生成 4-(2,3-dimethylphenyl)-N-(furan-2-ylmethyl)aniline
  参考文献：
  名称：

  One-pot Suzuki–Miyaura cross-coupling followed by reductive monoalkylation of the resulting nitro biaryl system utilizing Pd/C as catalyst

  摘要：

  Conditions for one-pot Suzuki-Miyaura cross-coupling between aryl boronic acids and bromo-nitrobenzene followed by reductive monoalkylation of the nitro functionality of the biaryl cross-coupling product utilizing hydrogen over Pd/C as the catalyst and aldehydes as alkylation agent are described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.128
• 作为产物：
  描述：

  2,3-dimethyl-4'-nitrobiphenyl 在 氢气 作用下， 以 乙醇 、 水 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 1.5h， 生成 4-(2,3-Dimethylphenyl)aniline
  参考文献：
  名称：

  One-pot Suzuki–Miyaura cross-coupling followed by reductive monoalkylation of the resulting nitro biaryl system utilizing Pd/C as catalyst

  摘要：

  Conditions for one-pot Suzuki-Miyaura cross-coupling between aryl boronic acids and bromo-nitrobenzene followed by reductive monoalkylation of the nitro functionality of the biaryl cross-coupling product utilizing hydrogen over Pd/C as the catalyst and aldehydes as alkylation agent are described. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.128

文献信息

• Polyol and utilization thereof
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0483431A1

  公开（公告）日：1992-05-06

  The present invention relates to a polyol, polyurethane resin, rigid polyurethane foam, preparation process thereof and a preparation process of a rigid polyurethane foam composite. The polyol used in the present invention comprises a phenol resin base polyol mixed with an aminophenol base polyol or a polyphenylpolyxylylenepolyamine base polyol or a polymethylenepolyphenylpolyamine base polyol. The above polyurethane resin, foam and composite have resistance to dissolution in a hydrochlorofluorocarbons and a hydrofluorocarbons which are foaming agents having very low public hagard. The above-mentioned foams have excellent physical properties equivalent to those of conventional polyurethane foams obtained by using chlorofluorocarbons, and hence are very useful as a thermal insulation material or a thermal insulation structure for refrigerators, freezers, insulation panels, ships or vehicles.

  本发明涉及一种多元醇、聚氨酯树脂、硬质聚氨酯泡沫塑料、其制备工艺和硬质聚氨酯泡沫塑料复合材料的制备工艺。 本发明中使用的多元醇包括酚醛树脂基多元醇与氨基苯酚基多元醇或聚苯聚氧乙烯聚胺基多元醇或聚亚甲基聚苯聚胺基多元醇的混合物。 上述聚氨酯树脂、泡沫和复合材料具有抗氯氟烃和氢氟烃溶解的性能，而氯氟烃和氢氟烃是公害极低的发泡剂。 上述泡沫塑料具有与使用氯氟化碳得到的传统聚氨酯泡沫塑料同等的优异物理性能，因此非常适用于冰箱、冰柜、隔热板、船舶或车辆的隔热材料或隔热结构。
• Selective inducible microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors derived from an oxicam template
  作者：Jane Wang、David Limburg、Jeff Carter、Gabriel Mbalaviele、James Gierse、Michael Vazquez

  DOI：10.1016/j.bmcl.2010.01.060

  日期：2010.3

  Here we describe the SAR of a series of potent and selective mPGES-1 inhibitors based on an oxicam template. Compound 13j demonstrated low nanomolar mPGES-1 inhibition in an enzyme assay. In addition, it displayed PGE(2) inhibition in a cell-based assay (0.42 mu M) and had over 238-fold selectivity for mPGES-1 over COX-2 and over 200-fold selectivity for mPGES-1 over 6-keto PGF(1 alpha). (C) 2010 Elsevier Ltd. All rights reserved.
• LXR AND FXR MODULATORS
  申请人：Exelixis, Inc.

  公开号：EP2121621A1

  公开（公告）日：2009-11-25
• DETECTING PAX2 FOR THE DIAGNOSIS OF BREAST CANCER
  申请人：Phigenix, Inc.

  公开号：EP2475779A1

  公开（公告）日：2012-07-18
• US5198475A
  申请人：——

  公开号：US5198475A

  公开（公告）日：1993-03-30