8-(4-hydroxycyclopent-2-en-1-on-2-yl)-1,2-octanediol | 80331-50-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-(4-hydroxycyclopent-2-en-1-on-2-yl)-1,2-octanediol
• 英文别名: 2-(7,8-dihydroxyoctyl)-4-hydroxycyclopent-2-en-1-one
• CAS: 80331-50-6
• 化学式: C₁₃H₂₂O₄
• 分子量: 242.315
• InChiKey: DFGKDSMOPUCUIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-(4-hydroxycyclopent-2-en-1-on-2-yl)-1,2-octanediol 、 三甲基氯硅烷 生成 2-(7,8-bistrimethylsilyloxyoctyl)-4-trimethylsilyloxycyclopent-2-en-1-one
  参考文献：
  名称：

  WISSNER, A.;FLOYD, M. B. ,, JR

  摘要：

  DOI：
• 作为产物：
  描述：

  9-(furan-2-yl)-1,2,9-nonanetriol 生成 8-(4-hydroxycyclopent-2-en-1-on-2-yl)-1,2-octanediol
  参考文献：
  名称：

  WISSNER, A.;FLOYD, M. B. ,, JR

  摘要：

  DOI：

文献信息

• 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04288630A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  本发明公开了一种前列腺素类似物，其α-链以基团-CH（OR'）OR"终止，其中R'和R"相同或不同，可以是氢，C.sub.1至C.sub.4烷酰基或可选取代苯甲酰基，所述取代基选择自C.sub.1至C.sub.4烷基，C.sub.1至C.sub.4烷氧基，卤素和三氟甲基。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂以及支气管扩张剂。
• 1-Hydroxymethyl-prosten-1-ol derivatives
  申请人：American Cyanamid Company

  公开号：US04289910A1

  公开（公告）日：1981-09-15

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  揭示了具有α-链以--CH(OR')OR"基结束的前列腺素类似物，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选取代苯甲酰基，所述取代基被选择自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基的群。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂以及支气管扩张剂。
• 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04288633A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  公开了α-链以--CH（OR')OR"基团终止的前列腺素类似物，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选取代苯甲酰基，所述取代基选择自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂和支气管扩张剂。
• 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
  申请人：American Cyanamid Company

  公开号：US04288629A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation inhibitors and bronchodilators.

  公开了α-链以--CH（OR'）OR"基团终止的前列腺素类似物，其中R'和R"相同或不同，并且是氢，C.sub.1到C.sub.4的烷酰基或可选的取代苯甲酰基，所述取代基选择自羟基和三氟甲基的C.sub.1到C.sub.4烷基，C.sub.1到C.sub.4烷氧基，卤素。这些化合物可用作降压剂，胃分泌和血小板聚集抑制剂和支气管扩张剂。
• 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives
  申请人：American Cyanamid Company

  公开号：US04288632A1

  公开（公告）日：1981-09-08

  Prostaglandin analogs are disclosed that have the .alpha.-chain terminating with the group --CH(OR')OR" wherein R' and R" are the same or different and are hydrogen, C.sub.1 to C.sub.4 alkanoyl or optionally substituted benzoyl, the substituents selected from the group C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, halo and trifluoromethyl. These compounds are useful as hypotensive agents, gastric secretory and platelet aggregation enhibitors and bronchodilators.

  公开了α-链以--CH（OR’）OR“基团终止的前列腺素类似物，其中R'和R"相同或不同，可以是氢、C.sub.1到C.sub.4烷酰基或可选取代苯甲酰基，所述取代基选择自C.sub.1到C.sub.4烷基、C.sub.1到C.sub.4烷氧基、卤素和三氟甲基的群。这些化合物可用作降压剂、胃分泌和血小板聚集抑制剂和支气管扩张剂。