1,1,1-tris(diphenylphosphanylmethyl)-2,2-dimethylpropane | 852954-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-tris(diphenylphosphanylmethyl)-2,2-dimethylpropane
• 英文别名: 1,1,1-tris(diphenylphosphinomethyl)-2,2-dimethylpropane；[2,2-Bis(diphenylphosphanylmethyl)-3,3-dimethylbutyl]-diphenylphosphane
• CAS: 852954-75-7
• 化学式: C₄₄H₄₅P₃
• 分子量: 666.763
• InChiKey: PKYMPJPNBFJTMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  47
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1,1-tris(diphenylphosphanylmethyl)-2,2-dimethylpropane 以 乙醚 、 氘代氯仿 为溶剂， 反应 27.0h， 生成 4,18,23-Tribromo-11-tert-butyl-9,9,13,13,28,28-hexakis-phenyl-1,8,14,27-tetraza-9lambda5,13lambda5,28lambda5-triphosphapentacyclo[9.9.9.13,7.115,19.122,26]dotriaconta-3,5,7(32),8,13,15(31),16,18,22,24,26(30),27-dodecaene
  参考文献：
  名称：

  调制所述螺旋桨状的一个三角架C（CH的形状2 PPH 2）3通过取代基的大小在macrobicyclic枢碳原子片段三λ 5 -phosphazenes

  摘要：

  手性macrobicyclic三λ 5个由三球三角架三（3-叠氮基苄）胺和1,1,1-三耦合形成-phosphazenes [（二苯基膦基）甲基]甲烷本螺旋拓扑作为将两个螺旋桨形的结果三脚架碎片具有相同的扭曲感。在低级叔丁烷片段R piv –C（CH 2 PPh 2）3的枢轴碳处引入一系列尺寸逐渐增加的R piv取代基，导致下部螺旋桨的螺旋度逐渐降低。这种现象被揭示在他们的CDCL 3溶液的NMR谱，和活化能为三λ的外消旋化过程5-磷腈通过聚结VT-NMR实验计算。

  DOI：

  10.1016/j.tet.2007.03.076
• 作为产物：
  描述：

  1,1,1-三(羟甲基)-2,2-二甲基丙烷 在 吡啶 、 氯化亚砜 、 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 反应 22.0h， 生成 1,1,1-tris(diphenylphosphanylmethyl)-2,2-dimethylpropane
  参考文献：
  名称：

  调制所述螺旋桨状的一个三角架C（CH的形状2 PPH 2）3通过取代基的大小在macrobicyclic枢碳原子片段三λ 5 -phosphazenes

  摘要：

  手性macrobicyclic三λ 5个由三球三角架三（3-叠氮基苄）胺和1,1,1-三耦合形成-phosphazenes [（二苯基膦基）甲基]甲烷本螺旋拓扑作为将两个螺旋桨形的结果三脚架碎片具有相同的扭曲感。在低级叔丁烷片段R piv –C（CH 2 PPh 2）3的枢轴碳处引入一系列尺寸逐渐增加的R piv取代基，导致下部螺旋桨的螺旋度逐渐降低。这种现象被揭示在他们的CDCL 3溶液的NMR谱，和活化能为三λ的外消旋化过程5-磷腈通过聚结VT-NMR实验计算。

  DOI：

  10.1016/j.tet.2007.03.076

文献信息

• METHOD FOR PRODUCING ALCOHOL BY HYDROGENATING LACTONE AND CARBOXYLIC ACID ESTER IN LIQUID PHASE
  申请人：Maeda Hirofumi

  公开号：US20100113842A1

  公开（公告）日：2010-05-06

  Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic efficiency. This method also enables to produce an optically active alcohol from an optically active lactone or an optically active carboxylic acid ester. Specifically disclosed is a method for producing an alcohol by hydrogen reducing a lactone or a carboxylic acid ester in the presence of a catalyst containing ruthenium and a phosphine compound represented by the following general formula (1): wherein R 1 represents a spacer; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 independently represent a hydrogen atom, an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group; and R 8 , R 9 , R 10 , R 11 , R 12 and R 13 independently represent an alkyl group having 1-12 carbon atoms, an aryl group or a heterocyclic group.

  本发明公开了一种从内酯或羧酸酯中制备醇的方法，该方法可以在相对温和的条件下高收率、高催化效率地从内酯或羧酸酯中制备醇。该方法还可以从手性内酯或手性羧酸酯中制备手性醇。具体公开了一种通过在催化剂中加入钌和以下通式（1）所代表的膦化合物的存在下，氢化还原内酯或羧酸酯制备醇的方法：其中R1代表间隔物，R2、R3、R4、R5、R6和R7分别独立地代表氢原子、具有1-12个碳原子的烷基、芳基或杂环基，R8、R9、R10、R11、R12和R13分别独立地代表具有1-12个碳原子的烷基、芳基或杂环基。
• Center-to-propeller and propeller-to-propeller stereocontrol in a series of macrobicyclic tri-λ5-phosphazenes
  作者：Mateo Alajarín、Carmen López-Leonardo、José Berná、Pilar Sánchez-Andrada

  DOI：10.1016/j.tetlet.2007.03.087

  日期：2007.5

  Center-to-propeller stereocontrol in a family of macrobicyclic, double-propeller shaped tri-lambda(5)-triphosphazenes remains constant in the upper tribenzylamine fragment as the size of the pivotal group at the lower tris(phosphane) fragment is gradually increased. In contrast the propeller-to-propeller stereocontrol diminishes as a result of the increasing conformational lability in the lower hemisphere. (C) 2007 Elsevier Ltd. All rights reserved.
• METHOD FOR PRODUCING ALCOHOL BY HYDROGENATING LACTONE OR CARBOXYLIC ACID ESTER IN LIQUID PHASE
  申请人：Takasago International Corporation

  公开号：EP2141142B1

  公开（公告）日：2015-03-04
• METHOD FOR RECOVERY AND RECYCLE OF RUTHENIUM HOMOGENEOUS CATALYSTS
  申请人：Eastman Chemical Company

  公开号：EP2605856A1

  公开（公告）日：2013-06-26
• PASSIVATION OF A HOMOGENEOUS HYDROGENATION CATALYST FOR THE PRODUCTION OF ETHYLENE GLYCOL
  申请人：Norman David William

  公开号：US20130253230A1

  公开（公告）日：2013-09-26

  A process for making ethylene glycol by feeding reactants including 1,2-dioxygenated organic compounds, an organometallic homogeneous catalyst, and hydrogen to a hydrogenation reactor, reacting at least a portion of the reactants with hydrogen in the presence of the organometallic homogeneous catalyst to produce a reaction product mixture containing ethylene glycol, and passivating the catalyst by contacting the catalyst with a carbon monoxide to thereby suppress the formation of by-product diols other thatn the ethylene glycol primary product, and suppress the formation of by-product tetrols and by-product glycolaldehyde acetals; and separating at least a portion of the ethylene glycol from the reaction product mixture.