2-methoxy-6-methoxymethoxybenzaldoxime | 820973-49-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-methoxy-6-methoxymethoxybenzaldoxime
• 英文别名: N-{[2-Methoxy-6-(methoxymethoxy)phenyl]methylidene}hydroxylamine；N-[[2-methoxy-6-(methoxymethoxy)phenyl]methylidene]hydroxylamine
• CAS: 820973-49-7
• 化学式: C₁₀H₁₃NO₄
• 分子量: 211.218
• InChiKey: JSTPAMWMLAJIRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  60.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-methoxy-6-methoxymethoxybenzaldoxime 在 sodium hydroxide 、 镍 作用下， 以 乙醇 为溶剂， 反应 1.5h， 以90%的产率得到[2-甲氧基-6-(甲氧基甲氧基)苯基]甲胺
  参考文献：
  名称：

  Monomers containing substrate or inhibitor residues for copper amine oxidases and their hydrophilic beaded resins designed for enzyme interaction studies

  摘要：

  Five styrenic monomers, four with aminoalkyl residues typical of copper containing amine oxidase substrates and one with a 2,6-dialkoxybenzylamine residue which mimics previously prepared selective substrate-like benzylamine oxidase inhibitors, have been synthesized and transformed into radical homopolymers, copolymers with N,N-dimethylacrylamide (DMAA), and hydrophilic beaded resins, designed for enzyme interaction studies aimed in finding new materials for highly biospecific chromatographic separations. The five monomers have given beaded resins of 125-500 mum swellable in water with a volume increase of 1200-1500%. The four aminoalkyl monomers have given water soluble copolymers some of which are good substrates of benzylamine oxidase (BAO), diamine oxidase (DAO) and lysyl oxidase (LO), up to 9.7 times better than elastin for LO. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.09.083
• 作为产物：
  描述：

  1-甲氧基-3-(甲氧基甲氧基)苯 在 吡啶 、 正丁基锂 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 1.5h， 生成 2-methoxy-6-methoxymethoxybenzaldoxime
  参考文献：
  名称：

  Monomers containing substrate or inhibitor residues for copper amine oxidases and their hydrophilic beaded resins designed for enzyme interaction studies

  摘要：

  Five styrenic monomers, four with aminoalkyl residues typical of copper containing amine oxidase substrates and one with a 2,6-dialkoxybenzylamine residue which mimics previously prepared selective substrate-like benzylamine oxidase inhibitors, have been synthesized and transformed into radical homopolymers, copolymers with N,N-dimethylacrylamide (DMAA), and hydrophilic beaded resins, designed for enzyme interaction studies aimed in finding new materials for highly biospecific chromatographic separations. The five monomers have given beaded resins of 125-500 mum swellable in water with a volume increase of 1200-1500%. The four aminoalkyl monomers have given water soluble copolymers some of which are good substrates of benzylamine oxidase (BAO), diamine oxidase (DAO) and lysyl oxidase (LO), up to 9.7 times better than elastin for LO. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.09.083

文献信息

• Monomers containing substrate or inhibitor residues for copper amine oxidases and their hydrophilic beaded resins designed for enzyme interaction studies
  作者：Vincenzo Bertini、Silvana Alfei、Marco Pocci、Francesco Lucchesini、Nevio Picci、Francesca Iemma

  DOI：10.1016/j.tet.2004.09.083

  日期：2004.12

  Five styrenic monomers, four with aminoalkyl residues typical of copper containing amine oxidase substrates and one with a 2,6-dialkoxybenzylamine residue which mimics previously prepared selective substrate-like benzylamine oxidase inhibitors, have been synthesized and transformed into radical homopolymers, copolymers with N,N-dimethylacrylamide (DMAA), and hydrophilic beaded resins, designed for enzyme interaction studies aimed in finding new materials for highly biospecific chromatographic separations. The five monomers have given beaded resins of 125-500 mum swellable in water with a volume increase of 1200-1500%. The four aminoalkyl monomers have given water soluble copolymers some of which are good substrates of benzylamine oxidase (BAO), diamine oxidase (DAO) and lysyl oxidase (LO), up to 9.7 times better than elastin for LO. (C) 2004 Elsevier Ltd. All rights reserved.