(S,Rp)- and (S,Sp)-methyl phenylhydroxymethylphosphinate | 250782-57-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S,Rp)- and (S,Sp)-methyl phenylhydroxymethylphosphinate
• 英文别名: (S)-methoxyphosphonoyl(phenyl)methanol
• CAS: 250782-57-1
• 化学式: C₈H₁₁O₃P
• 分子量: 186.147
• InChiKey: KYRLVCFMJKUYSB-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S,Rp)- and (S,Sp)-methyl phenylhydroxymethylphosphinate 在 二异丁基氢化铝 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 13.0h， 生成 dl-methyl bis(α-hydroxyphenylmethyl)phosphinate
  参考文献：
  名称：

  Enantioselective synthesis of α-hydroxyphosphinic acid derivatives through hydrophosphinylation of aldehydes catalyzed by Al-Li-BINOL complex

  摘要：

  The first catalytic asymmetric synthesis of (S)-alpha-hydroxy-H-phosphinates and (S,S)-alpha,alpha'-dihydroxyphosphinates were achieved by the reaction of methyl phosphinate with aldehydes in the presence of Al-Li-BINOL complex. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00709-7
• 作为产物：
  描述：

  methyl hypophosphite 、 苯甲醛 在 Al-Li-(R,R')-2,2'-dihydroxy-1,1'-binaphthyl 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 、 (S,Rp)- and (S,Sp)-methyl phenylhydroxymethylphosphinate
  参考文献：
  名称：

  Enantioselective synthesis of α-hydroxyphosphinic acid derivatives through hydrophosphinylation of aldehydes catalyzed by Al-Li-BINOL complex

  摘要：

  The first catalytic asymmetric synthesis of (S)-alpha-hydroxy-H-phosphinates and (S,S)-alpha,alpha'-dihydroxyphosphinates were achieved by the reaction of methyl phosphinate with aldehydes in the presence of Al-Li-BINOL complex. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00709-7