(4R,5S)-4-(methoxycarbonyl)-5-(2,5-dimethoxyphenyl)-N-tosyl-2-imidazoline | 1245746-90-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (4R,5S)-4-(methoxycarbonyl)-5-(2,5-dimethoxyphenyl)-N-tosyl-2-imidazoline
• CAS: 1245746-90-0
• 化学式: C₂₀H₂₂N₂O₆S
• 分子量: 418.47
• InChiKey: OZULVPICTVJQJR-MOPGFXCFSA-N

反应信息

• 作为产物：
  描述：

  N-(2,5-dimethoxybenzylidene)-4-methylbenzenesulfonamide 、 异腈基乙酸甲酯 在 (S)-(6-hydroxyquinolin-4-yl)((2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl acetate 作用下， 以 甲苯 为溶剂， 反应 84.0h， 生成 (4R,5S)-4-(methoxycarbonyl)-5-(2,5-dimethoxyphenyl)-N-tosyl-2-imidazoline 、 (4S,5R)-4-(methoxycarbonyl)-5-(2,5-dimethoxyphenyl)-N-tosyl-2-imidazoline
  参考文献：
  名称：

  Organocatalytic asymmetric Mannich-type reaction of N-sulfonylimines with isocyanoacetate leading to optically active 2-imidazoline-4-carboxylates

  摘要：

  The first asymmetric Mannich-type reaction of methyl isocyanoacetate with N-sulfonylimines catalyzed by cinchona alkaloid derivatives yielded 2-imidazolines with high diastereoselectivities and good enantioselectivities (up to >99:1 dr and 70% ee). This reaction provided a convenient route to access various substituted 2-imidazoline-4-carboxylates and related alpha,beta-diamino acids in high enantiomeric purities. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.029