| 1240503-06-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1240503-06-3
• 化学式: C₆₃H₁₀₂N₁₀O₆
• 分子量: 1095.57
• InChiKey: SELMHWGSTDBHRS-HKQVNRQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.23
• 重原子数：
  79.0
• 可旋转键数：
  46.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  278.68
• 氢给体数：
  10.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  N-succinimidyl 4-guanidinobutyrate 、 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Oligopeptide Delivery Carrier for Osteoclast Precursors

  摘要：

  Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 mu g/mL against the cells.

  DOI：

  10.1021/bc100066k
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Oligopeptide Delivery Carrier for Osteoclast Precursors

  摘要：

  Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 mu g/mL against the cells.

  DOI：

  10.1021/bc100066k