2-[(2-tert-butoxycarbonylamino-3-phenylpropionyl)trimethylsilanylmethylamino]-3-phenylpropionic acid methyl ester | 916049-51-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(2-tert-butoxycarbonylamino-3-phenylpropionyl)trimethylsilanylmethylamino]-3-phenylpropionic acid methyl ester
• CAS: 916049-51-9
• 化学式: C₂₈H₄₀N₂O₅Si
• 分子量: 512.721
• InChiKey: GBEUMUGOSMFNFN-ZEQRLZLVSA-N

物化性质

• 沸点：
  622.3±55.0 °C(Predicted)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.61
• 重原子数：
  36.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  84.94
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-[(2-tert-butoxycarbonylamino-3-phenylpropionyl)trimethylsilanylmethylamino]-3-phenylpropionic acid methyl ester 、 乙醇 在 tetrabutylammonium tetrafluoroborate 作用下， 以59%的产率得到2-[N-(2-tert-butoxycarbonylamino-3-phenylpropionyl)-N-ethoxymethylamino]-3-phenylpropionic acid methyl ester
  参考文献：
  名称：

  Building Functionalized Peptidomimetics:  Use of Electroauxiliaries for Introducing N-Acyliminium Ions into Peptides

  摘要：

  A series of silyl-substituted amino acids have been synthesized, inserted into peptides, and then employed as precursors for oxidatively generating reactive N-acyliminium ions. Both electrochemical and chemical oxidation procedures have been employed. N-Acyliminium ion generation in a solid-phase substrate as well as application to a small library of functionalized dipeptides has been demonstrated. Limitations in terms of how electron-rich the silyl groups can be as well as the compatibility of multiple silyl groups within a longer peptide are defined.

  DOI：

  10.1021/ja064737l
• 作为产物：
  描述：

  L-苯丙氨酸甲酯盐酸盐 在 potassium carbonate 、 potassium iodide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 生成 2-[(2-tert-butoxycarbonylamino-3-phenylpropionyl)trimethylsilanylmethylamino]-3-phenylpropionic acid methyl ester
  参考文献：
  名称：

  Building Functionalized Peptidomimetics:  Use of Electroauxiliaries for Introducing N-Acyliminium Ions into Peptides

  摘要：

  A series of silyl-substituted amino acids have been synthesized, inserted into peptides, and then employed as precursors for oxidatively generating reactive N-acyliminium ions. Both electrochemical and chemical oxidation procedures have been employed. N-Acyliminium ion generation in a solid-phase substrate as well as application to a small library of functionalized dipeptides has been demonstrated. Limitations in terms of how electron-rich the silyl groups can be as well as the compatibility of multiple silyl groups within a longer peptide are defined.

  DOI：

  10.1021/ja064737l